β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems

被引：64
作者：
Aykac, Ahmet [1 ]
Martos-Maldonado, Manuel C. [1 ]
Casas-Solvas, Juan M. [1 ]
Quesada-Soriano, Indalecio [1 ]
Garcia-Maroto, Federico [1 ]
Garcia-Fuentes, Luis [1 ]
Vargas-Berenguel, Antonio [1 ]
机构：
[1] Univ Almeria, Dept Chem & Phys, Almeria 04120, Spain
来源：
LANGMUIR | 2014年 / 30卷 / 01期
关键词：
P-GLYCOPROTEIN; BIOMOLECULAR RECOGNITION; SUPRAMOLECULAR CHEMISTRY; OLIGO(ETHYLENE GLYCOL); COLORIMETRIC DETECTION; NANOPARTICLES; LECTIN; LIGAND; CHOLESTEROL; AGGREGATION;
D O I：
10.1021/la403454p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three novel gold nanoparticles containing multiple long, flexible linkers decorated with lactose, beta-cyclodextrin, and both simultaneously have been prepared. The interaction of such nanoparticles with beta-D-galactose-recognizing lectins peanut agglutinin (PNA) and human galectin-3 (Gal-3) was demonstrated by UV-vis studies. Gal-3 is well-known to be overexpressed in several human tumors and can act as a biorecognizable target. This technique also allowed us to estimate their loading capability toward the anticancer drug methotrexate (MTX). Both results make these glyconanoparticles potential site-specific delivery systems for anticancer drugs.
引用
收藏
页码：234 / 242
页数：9
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