Red-emitting pyrene-benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect

被引：36

作者：

Abeywickrama, Chathura S. ^{[1
]}

Wijesinghe, Kaveesha J. ^{[2
]}

Stahelin, Robert V. ^{[3
]}

Pang, Yi ^{[1
,4
]}

机构：

[1] Univ Akron, Dept Chem, Akron, OH 44325 USA

[2] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

[3] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

[4] Univ Akron, Maurice Morton Inst Polymer Sci, Akron, OH 44325 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 24期

关键词：

LARGE STOKES SHIFT; FLUORESCENT-PROBES; CATHEPSIN-B; LIVE CELLS; AUTOPHAGY; CYANINE; CANCER; APOLAR; DEATH; DYES;

D O I：

10.1039/c9cc01068h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of pyrene-benzothiazolium probes were synthesized. By replacing the pyridinium with a benzothiazolium unit, the selectivity of pyrene-derivatives is found to switch from nuclear to cellular lysosomes. New probes do not require proton participation and exhibit high biocompatibility and long-term imaging ability.

引用

收藏

页码：3469 / 3472

页数：4

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