Copper-Catalyzed Tandem Azide-Alkyne Cycloaddition, Ullmann Type C-N Coupling, and Intramolecular Direct Arylation

被引：94

作者：

Pericherla, Kasiviswanadharaju ^{[1
,2
]}

Jha, Amitabh ^{[2
]}

Khungar, Bharti ^{[1
]}

Kumar, Anil ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India

[2] Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 17期

基金：

加拿大自然科学与工程研究理事会;

关键词：

FUNCTIONALIZATION; DERIVATIVES; ARYL;

D O I：

10.1021/ol401655r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ligand-free copper-catalyzed tandem azide-alkyne cycloaddition (CuAAC), Ullmann-type C-N coupling, and intramolecular direct arylation has been described. The designed strategy resulted in the synthesis of a novel trazole-fused azaheterocycle framework. The reaction gave good yields (59-77%) of 1,2,3-triazole-fused imidazo[1,2-a]pyridines in a single step.

引用

页码：4304 / 4307

页数：4

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