Cell culture and animal models for human viral hepatitis

被引：1

作者：

Olive, DS ^{[1
]}

Konishi, M ^{[1
]}

Wu, GY ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Gastroenterol Hepatol, Farmington, CT 06030 USA

来源：

HEPATOLOGY RESEARCH | 2004年 / 28卷 / 02期

关键词：

human viral hepatitis; cell culture models; animal models;

D O I：

10.1016/j.hepres.2003.09.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Human hepatitis viruses are currently the subjects of intense investigation because of the tremendous clinical impact of these agents on human health. For other viral infections, cell culture and animal models have played crucial roles in the development of vaccines and drug therapies as well as characterization of viral life cycles. However, for human hepatitis viruses, models have been limited. The chimpanzee model is considered to be the most valuable, because it provides the closest match to clinical human hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Due to the expense and short supply, however, the use of this model is restricted. Thus, there is a great demand for the development of new convenient animal models of human hepatitis viral infection. This review will focus current cell culture and animal models to study HBV and HCV. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：61 / 67

页数：7

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