Enantioselective syntheses of key A-ring precursors of 1α, 25-dihydroxyvitamin D3 and analogues

被引：0

作者：

Anné, S ^{[1
]}

Yong, W ^{[1
]}

Vandewalle, M ^{[1
]}

机构：

[1] State Univ Ghent, Dept Organ Chem, Organ Synth Lab, B-9000 Ghent, Belgium

来源：

SYNLETT | 1999年 / 09期

关键词：

1; alpha; 25-dihydroxyvitamin D-3; catalytic enantioselective aldol; 1,3-anti-diol; Pummerer reaction; Tebbe reaction;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of (3S, 5R) oct-1-en-7-yne-3,5-diol derivatives 7 involving a catalytic enantioselective aldol reaction is described. Also a new synthesis of (3S, 5R) non-1-en-7-yne-3,5,9-triol derivatives 3, starting from (2S, 4S)-1,2:4,5-diepoxy-pentane 2 is reported.

引用

页码：1435 / 1437

页数：3

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