Alginate-Hydroxyapatite Bone Scaffolds with Isotropic or Anisotropic Pore Structure: Material Properties and Biological Behavior

被引：26
|
作者：
Porrelli, Davide [1 ]
Travan, Andrea [1 ]
Turco, Gianluca [2 ]
Marsich, Eleonora [2 ]
Borgogna, Massimiliano [1 ]
Paoletti, Sergio [1 ]
Donati, Ivan [1 ]
机构：
[1] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy
[2] Univ Trieste, Dept Med Surg & Hlth Sci, I-34129 Trieste, Italy
来源：
MACROMOLECULAR MATERIALS AND ENGINEERING | 2015年 / 300卷 / 10期
关键词：
biological applications of polymers; fillers; ISISA; oriented pores; shape recovery; MARROW STROMAL CELLS; COMPOSITE SCAFFOLDS; CANCELLOUS BONE; TISSUE; REPAIR; DELIVERY; GROWTH; GLASS; HYDROGEL; INGROWTH;
D O I：
10.1002/mame.201500055
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Alginate/hydroxyapatite composites, with isotropic or anisotropic porosity, were developed using two different freezing methods. Morphological analysis highlighted the differences in their three-dimensional network. Swelling and in vitro degradation studies revealed that both structures are highly hydrophilic and stable. Static compression tests showed that isotropic scaffolds possess higher modulus and toughness than anisotropic ones. Cyclic compression tests revealed that wet scaffolds are able to withstand high deformations with a peculiar shape-recovery behaviour. In vitro biological tests showed that osteoblast-like cells proliferate on both types of structures in a comparable manner.
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收藏
页码：989 / 1000
页数：12
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