Genes expressed in dental enamel development are associated with molar-incisor hypomineralization

被引：129

作者：

Jeremias, Fabiano ^{[1
]}

Koruyucu, Mine ^{[3
]}

Kuechler, Erika C. ^{[4
]}

Bayram, Merue ^{[3
]}

Tuna, Elif B. ^{[3
]}

Deeley, Kathleen ^{[4
]}

Pierri, Ricardo A. ^{[1
]}

Souza, Juliana F. ^{[1
]}

Fragelli, Camila M. B. ^{[1
]}

Paschoal, Marco A. B. ^{[1
]}

Gencay, Koray ^{[3
]}

Seymen, Figen ^{[3
]}

Caminaga, Raquel M. S. ^{[2
]}

dos Santos-Pinto, Lourdes ^{[1
]}

Vieira, Alexandre R. ^{[4
,5
]}

机构：

[1] Sao Paulo State Univ, Sch Dent Araraquara, Dept Pediat Dent, UNESP, Araraquara, SP, Brazil

[2] Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, UNESP, Araraquara, SP, Brazil

[3] Istanbul Univ, Fac Dent, Dept Pedodont, Istanbul, Turkey

[4] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Sch Dent Med, Dept Pediat Dent, Pittsburgh, PA 15261 USA

来源：

ARCHIVES OF ORAL BIOLOGY | 2013年 / 58卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

Dental enamel; Amelogenesis; Dental enamel hypoplasia; Dental caries; Dental caries susceptibility; HIGH CARIES EXPERIENCE; AMELOGENIN; TUFTELIN; SCAN; PREVALENCE; FAMILIES; MUTATION;

D O I：

10.1016/j.archoralbio.2013.05.005

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Genetic disturbances during dental development influence variation of number and shape of the dentition. In this study, we tested if genetic variation in enamel formation genes is associated with molar-incisor hypomineralization (MIH), also taking into consideration caries experience. DNA samples from 163 cases with MIH and 82 unaffected controls from Turkey, and 71 cases with MIH and 89 unaffected controls from Brazil were studied. Eleven markers in five genes [ameloblastin (AMBN), amelogenin (AMELX), enamelin (ENAM), tuftelin (TUFT1), and tuftelin-interacting protein 11 (TFIP11)] were genotyped by the TaqMan method. Chi-square was used to compare allele and genotype frequencies between cases with MIH and controls. In the Brazilian data, distinct caries experience within the MIH group was also tested for association with genetic variation in enamel formation genes. The ENAM rs3796704 marker was associated with MIH in both populations (Brazil: p = 0.03; OR = 0.28; 95% C.I. = 0.06-1.0; Turkey: p = 1.22e-012; OR = 17.36; 95% C.I. = 5.98-56.78). Associations between TFIP11 (p = 0.02), ENAM (p = 0.00001), and AMELX (p = 0.01) could be seen with caries independent of having MIH or genomic DNA copies of Streptococcus mutans detected by real time PCR in the Brazilian sample. Several genes involved in enamel formation appear to contribute to MIH. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1434 / 1442

页数：9

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