Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation

被引：28

作者：

Chang, Tsuhen M. ^{[1
]}

Tomat, Elisa ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

来源：

DALTON TRANSACTIONS | 2013年 / 42卷 / 22期

关键词：

IRON(III) COMPLEXES; LOW-SPIN; ANTIPROLIFERATIVE AGENTS; RIBONUCLEOTIDE REDUCTASE; NITRILE HYDRATASE; N; S COORDINATION; BREAST-CANCER; OVERLOAD; CELLS; DISEASE;

D O I：

10.1039/c3dt50824b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.

引用

页码：7846 / 7849

页数：4

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