Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

被引：39
|
作者：
Coppin, Lucie [1 ,2 ,3 ]
Leclerc, Julie [1 ,2 ,3 ]
Vincent, Audrey [1 ,2 ,3 ]
Porchet, Nicole [1 ,2 ,3 ]
Pigny, Pascal [1 ,2 ,3 ]
机构：
[1] Univ Lille, Jean Pierre Aubert Res Ctr, UMR S 1172, F-59000 Lille, France
[2] INSERM, UMR S 1172, Team Mucins Epithelial Differentiat & Carcinogene, F-59000 Lille, France
[3] CHU Lille, Serv Biochim Hormonol, Metab Nutr, Oncol, F-59000 Lille, France
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 03期
关键词：
mRNA life-cycle; mRNA fate; mRNA-binding proteins; mRNA-binding domains; intrinsically disordered regions; low complexity disordered regions; cytoplasmic RNA granules; DNA and RNA-binding proteins; RNA regulon; galectin-3; GENE-EXPRESSION; SPLICING FACTORS; NUCLEAR EXPORT; POLY(A)-BINDING PROTEINS; TRANSLATIONAL CONTROL; SR PROTEINS; GALECTIN-3; MICRORNAS; MECHANISMS; HUR;
D O I：
10.3390/ijms19030650
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies.
引用
收藏
页数：26
相关论文
共 50 条
  • [1] The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei
    Kolev, Nikolay G.
    Ullu, Elisabetta
    Tschudi, Christian
    CELLULAR MICROBIOLOGY, 2014, 16 (04) : 482 - 489
  • [2] The emerging landscape of non-conventional RNA functions in atherosclerosis
    Farina, Floriana Maria
    Weber, Christian
    Santovito, Donato
    ATHEROSCLEROSIS, 2023, 374 : 74 - 86
  • [3] Emerging Roles of NANOS RNA-Binding Proteins in Cancer
    Ilaslan, Erkut
    Sajek, Marcin Piotr
    Jaruzelska, Jadwiga
    Kusz-Zamelczyk, Kamila
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (16)
  • [4] Role of PUM RNA-Binding Proteins in Cancer
    Smialek, Maciej J.
    Ilaslan, Erkut
    Sajek, Marcin P.
    Jaruzelska, Jadwiga
    CANCERS, 2021, 13 (01) : 1 - 13
  • [5] Emerging roles of RNA and RNA-binding protein network in cancer cells
    Kim, Mee Young
    Hur, Jung
    Jeong, Sunjoo
    BMB REPORTS, 2009, 42 (03) : 125 - 130
  • [6] MESSENGER RIBONUCLEOPROTEINS (INFORMOSOMES) AND RNA-BINDING PROTEINS
    SPIRIN, AS
    MOLECULAR BIOLOGY REPORTS, 1979, 5 (1-2) : 53 - 57
  • [7] Comparative life-cycle assessment of conventional (double lane) and non-conventional (turbo and flower) roundabout intersections
    Mauro, Raffaele
    Guerrieri, Marco
    TRANSPORTATION RESEARCH PART D-TRANSPORT AND ENVIRONMENT, 2016, 48 : 96 - 111
  • [8] Emerging Roles of RNA-Binding Proteins in Neurodevelopment
    Parra, Amalia S.
    Johnston, Christopher A.
    JOURNAL OF DEVELOPMENTAL BIOLOGY, 2022, 10 (02)
  • [9] RNA-binding proteins and RNA methylation in myeloid cells*
    Bataclan, Marian
    Leoni, Cristina
    Monticelli, Silvia
    IMMUNOLOGICAL REVIEWS, 2021, 304 (01) : 51 - 61
  • [10] RNA-Binding Proteins: A Role in Neurotoxicity?
    Ocharan-Mercado, Andrea
    Loaeza-Loaeza, Jaqueline
    Castro-Coronel, Yaneth
    Acosta-Saavedra, Leonor C.
    Hernandez-Kelly, Luisa C.
    Hernandez-Sotelo, Daniel
    Ortega, Arturo
    NEUROTOXICITY RESEARCH, 2023, 41 (06) : 681 - 697
12345