Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide

被引：4
作者：
Wu, Yu-Shan [1 ]
Liao, Zih-Jie [1 ]
Wang, Kai-Shiuan [1 ]
Lung, Feng-Di T. [1 ]
机构：
[1] Tunghai Univ, Dept Chem, Taichung 40704, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 10期
关键词：
Antimicrobial peptides; Ixosin-B; Antimicrobial activity; Hemolytic activity; LACTOFERRICIN; TRYPTOPHAN;
D O I：
10.1016/j.bmcl.2013.03.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
There is a great urgency in developing a new generation of antibiotics and antimicrobial agents since the bacterial resistance to antibiotics have increased dramatically. A series of overlapped peptide fragments of Ixosin-B, an antimicrobial peptide with amino acid sequence of QLKVDLWGTRSGIQ-PEQHSSGKSDVRRWRSRY, was designed, synthesized and examined for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. A potent 11-mer peptide TSG-8-1, WWSYVRRWRSR-amide, was developed, which exhibited antimicrobial activity against E. coli and S. aureus while very little hemolytic activity in human erythrocytes was observed at high dose level. This peptide could be further modified for the development of a potent antimicrobial agent in the future. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2929 / 2932
页数：4
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