Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets

被引：42

作者：

Pires de Mello, Camilly P. ^{[1
]}

Bloom, David C. ^{[2
]}

Paixao, Izabel C. N. P. ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Biol, Dept Cellular & Mol Biol, Niteroi, RJ, Brazil

[2] Univ Florida, Coll Med, Dept Microbiol & Mol Genet, Gainesville, FL USA

来源：

ANTIVIRAL THERAPY | 2016年 / 21卷 / 04期

关键词：

PROMOTER-REGULATORY DOMAINS; IMMEDIATE-EARLY GENES; NERVE GROWTH-FACTOR; ENTRY MEDIATOR; IN-VITRO; HERPES-SIMPLEX-VIRUS-1; GH; BINDING PROTEIN; SENSORY NEURONS; GLYCOPROTEIN B; PORTAL VERTEX;

D O I：

10.3851/IMP3018

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Infection by herpes simplex virus type-1 (HSV-1) causes several diseases, ranging from cutaneous, oral and genital infections to fatal encephalitis. Despite the availability of antiviral therapies on the market, their efficacies are incomplete, and new cases of resistant strains arise, mainly in the immunocompromised, but also recently documented in immunocompetent patients. Over the last decades a lot has been discovered about the molecular basis of infection which has been of great benefit to the investigation of new anti-HSV-1 molecules. In this review we summarize replication, latency and reactivation highlighting potential antiviral targets and new molecules described in the past several years in the literature.

引用

页码：277 / 286

页数：10

共 126 条

[1] The Effects of the Diterpenes Isolated from the Brazilian Brown Algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle [J].

Abrantes, Juliana L. ;

Barbosa, Jussara ;

Cavalcanti, Diana ;

Pereira, Renato C. ;

Fontes, Carlos Frederico L. ;

Teixeira, Valeria L. ;

Souza, Thiago Moreno L. ;

Paixao, Izabel C. P. .

PLANTA MEDICA, 2010, 76 (04) :339-344

[2] Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [J].

Akhtar, Jihan ;

Shukla, Deepak .

FEBS JOURNAL, 2009, 276 (24) :7228-7236

[3] Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency [J].

Allen, Sariah J. ;

Rhode-Kurnow, Antje ;

Mott, Kevin R. ;

Jiang, Xianzhi ;

Carpenter, Dale ;

Ignacio Rodriguez-Barbosa, J. ;

Jones, Clinton ;

Wechsler, Steven L. ;

Ware, Carl F. ;

Ghiasi, Homayon .

JOURNAL OF VIROLOGY, 2014, 88 (04) :1961-1971

[4] Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics [J].

Antoine, Thessicar E. ;

Park, Paul J. ;

Shukla, Deepak .

REVIEWS IN MEDICAL VIROLOGY, 2013, 23 (03) :194-208

[5] In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease [J].

Aubert, Martine ;

Boyle, Nicole M. ;

Stone, Daniel ;

Stensland, Laurence ;

Huang, Meei-Li ;

Magaret, Amalia S. ;

Galetto, Roman ;

Rawlings, David J. ;

Scharenberg, Andrew M. ;

Jerome, Keith R. .

MOLECULAR THERAPY-NUCLEIC ACIDS, 2014, 3

[6] A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events [J].

Bag, Paromita ;

Ojha, Durbadal ;

Mukherjee, Hemanta ;

Halder, Umesh C. ;

Mondal, Supriya ;

Biswas, Aruna ;

Sharon, Ashoke ;

Van Kaer, Luc ;

Chakrabarty, Sekhar ;

Das, Gobardhan ;

Mitra, Debashis ;

Chattopadhyay, Debprasad .

ANTIVIRAL RESEARCH, 2014, 105 :126-134

[7] Inhibition of HSV-1 Attachment, Entry, and Cell-to-Cell Spread by Functionalized Multivalent Gold Nanoparticles [J].

Baram-Pinto, Dana ;

Shukla, Sourabh ;

Gedanken, Aharon ;

Sarid, Ronit .

SMALL, 2010, 6 (09) :1044-1050

[8] Histone modifications and nuclear architecture:: A review [J].

Bartova, Eva ;

Krejci, Jana ;

Harnicarova, Andrea ;

Galiova, Gabriela ;

Kozubek, Stanislav .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2008, 56 (08) :711-721

[9] Exploring the Balance between DNA Pressure and Capsid Stability in Herpesviruses and Phages [J].

Bauer, D. W. ;

Li, D. ;

Huffman, J. ;

Homa, F. L. ;

Wilson, K. ;

Leavitt, J. C. ;

Casjens, S. R. ;

Baines, J. ;

Evilevitch, A. .

JOURNAL OF VIROLOGY, 2015, 89 (18) :9288-9298

[10] Herpes Virus Genome, The Pressure Is On [J].

Bauer, David W. ;

Huffman, Jamie B. ;

Homa, Fred L. ;

Evilevitch, Alex .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (30) :11216-11221

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