CD8+ T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2b Mice

被引：7

作者：

Walsh, Kevin B. ^{[1
]}

Sidney, John ^{[2
]}

Welch, Megan ^{[1
]}

Fremgen, Daniel M. ^{[1
]}

Sette, Alessandro ^{[2
]}

Oldstone, Michael B. A. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] La Jolla Inst Allergy & Immunol, Ctr Infect Dis, La Jolla, CA USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 17期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; MACROPHAGE-INFLAMMATORY PROTEIN-1-ALPHA; INFECTION; RESPONSES; DISEASE; PVM; DEGRANULATION; CULTURE; HOST;

D O I：

10.1128/JVI.00339-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8(+) T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8(+) T-cell epitopes restricted by H-2D(b) and/or H-2K(b) were identified. These data open the door for using widely profiled, genetically manipulated C57BL/6 mice to study the contribution of epitope-specific CD8(+) T cells to PVM pathogenesis.

引用

页码：9949 / 9952

页数：4

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