Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortex

被引：29

作者：

Holt, RA ^{[1
]}

Bateson, AN ^{[1
]}

Martin, IL ^{[1
]}

机构：

[1] UNIV ALBERTA,DIV NEUROSCI,EDMONTON,AB T6G 2H7,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 329卷 / 2-3期

关键词：

benzodiazepine tolerance; gene expression; coordinate gene regulation;

D O I：

10.1016/S0014-2999(97)00168-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of chronic zolpidem treatment on the steady-state levels of gamma-aminobutyric acid(A) alpha 1-6, beta 1-3 and gamma 1-3 subunit mRNAs in rat cortex has been investigated. Male Sprague-Dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. The levels of the alpha 4 and beta 1 subunit mRNAs were significantly increased after 7 days of treatment and the level of alpha 1 subunit mRNA was significantly decreased after 14 days of treatment, as determined by solution hybridization. These results are compared to the previously determined effects of an equivalent schedule of treatment with diazepam. (C) 1997 Elsevier Science B.V.

引用

页码：129 / 132

页数：4

共 20 条

[1]

BENAVIDES J, 1992, J PHARMACOL EXP THER, V263, P884

[2] Molecular mechanisms of benzodiazepine-induced downregulation of GABA(A) receptor alpha(1) subunit protein in rat cerebellar granule cells [J].