Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells

被引：4

作者：

Jeon, Ki Beom ^{[1
]}

Lee, Seong Hun ^{[2
]}

Kwon, Yong Seong ^{[2
]}

Beak, Jin Hong ^{[2
]}

Lee, Hyeon ^{[1
]}

Ma, Choong Je ^{[3
,4
,5
,6
]}

机构：

[1] Beauty Sci Ltd, R&DB Ctr, Sejong, South Korea

[2] KJM Aloe Co Ltd, R&D Ctr, Seoul, South Korea

[3] Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biomat Engn, Chunchon, South Korea

[4] Kangwon Natl Univ, Inst Biosci & Biotechnol, Chunchon, South Korea

[5] Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biomat Engn, Chunchon 24341, South Korea

[6] Kangwon Natl Univ, Inst Biosci & Biotechnol, Chunchon 24341, South Korea

来源：

ANIMAL CELLS AND SYSTEMS | 2022年 / 26卷 / 06期

关键词：

Aloe arborescens; aloenin; aloin; neuroprotection; oxidative stress; AMYLOID-BETA-PEPTIDE; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; DYSFUNCTION;

D O I：

10.1080/19768354.2022.2147584

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Excessive glutamate can cause oxidative stress in neuronal cells and this can significantly contribute to the etiology of neurodegenerative disease. The present study mainly aims to investigate that aloe extract (AE) and fermented aloe extract (FAE) could protect against glutamate-induced cytotoxicity by modulating oxidative stress. In this study, both AE and FAE showed potent neuroprotective activity by inhibiting ROS and Ca2+ concentration, increasing mitochondria membrane potential, and activating glutathione-related enzymes against glutamate-insulted neurotoxicity in HT22 cells. In addition, the neuroprotective activity of FAE was more potent than that of AE. HPLC analysis reveals that the chemical composition of FAE is different from that of AE. Especially, the contents of aloin A, aloin B and aloenin were higher in FAE than in AE. In conclusion, this study indicates that both AE and FAE may have effective neuroprotective activity in glutamate-insulted pathological conditions such as Alzheimer's disease by managing oxidative stress.

引用

页码：318 / 327

页数：10

共 43 条

[31] Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks [J].