Case report: Cutaneous pseudolymphoma caused by a Leishmania infantum infection in a patient treated with anti-TNF antibody for plaque psoriasis

被引：0

作者：

Scholl, Sarah ^{[1
]}

Schuster, Daniel ^{[1
]}

Technau-Hafsi, Kristin ^{[1
]}

Stete, Katarina ^{[2
]}

Rieg, Siegbert ^{[2
]}

May, Annette M. ^{[3
,4
]}

Bogdan, Christian ^{[5
,6
]}

Schauer, Franziska ^{[1
]}

机构：

[1] Univ Freiburg, Fac Med, Med Ctr, Dept Dermatol, Freiburg, Germany

[2] Univ Hosp Freiburg, Dept Med 2, Div Infect Dis, Freiburg, Germany

[3] Univ Freiburg, Inst Clin Pathol, Fac Med, Med Ctr, Freiburg, Germany

[4] Inst Dermatohistol Pathol Mol Pathol Prof Dr Helmu, Freiburg, Germany

[5] Friedrich Alexander Univ FAU Erlangen Nurnberg, Mikrobiol Inst, Klin Mikrobiol Immunol & Hyg, Univ Klinikum Erlangen, Erlangen, Germany

[6] Friedrich Alexander Univ FAU Erlangen Nurnberg, Med Immunol Campus Erlangen, Erlangen, Germany

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

关键词：

skin pseudolymphoma; cutaneous leishmaniasis; anti-TNF therapy; adalimumab; skin ulceration; DOUBLE-BLIND; INFLIXIMAB; ADALIMUMAB;

D O I：

10.3389/fmed.2022.1055703

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For psoriasis, which affects up to 2% of the population and adalimumab is approved from the age of 4 years. Here, we present a middle-aged Italian man with long-term history of plaque psoriasis and psoriasis arthropathica and adalimumab therapy. He developed ulcers or nodules within the psoriatic plaques, resembling cutaneous infection with Leishmania infantum. TNF and other cytokines such as IL-12 and IFN-gamma are central in the early control of the infection. Discontinuation of the anti-TNF-treatment resolved the infection without specific therapy.

引用

页数：5

共 20 条

[1] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [I]: anti-tumor necrosis factor-α agents) [J].

Baddley, J. W. ;

Cantini, F. ;

Goletti, D. ;

Gomez-Reino, J. J. ;

Mylonakis, E. ;

San-Juan, R. ;

Fernandez-Ruiz, M. ;

Torre-Cisneros, J. .

CLINICAL MICROBIOLOGY AND INFECTION, 2018, 24 :S10-S20

[2] Diagnosis and therapy of cutaneous and mucocutaneous Leishmaniasis in Germany [J].

Boecken, Gerhard ;

Sunderkoetter, Cord ;

Bogdan, Christian ;

Weitzel, Thomas ;

Fischer, Marcellus ;

Mueller, Andreas ;

Loebermann, Micha ;

Anders, Gerlind ;

von Stebut, Esther ;

Schunk, Mirjam ;

Burchard, Gerd ;

Grobusch, Martin ;

Bialek, Ralf ;

Harms-Zwingenberger, Gundel ;

Fleischer, Bernhard ;

Pietras, Mathias ;

Faulde, Michael ;

Erkens, Kay .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2011, 9 :1-51

[3]

Bogdan Christian, 2020, Cytokine X, V2, P100041, DOI 10.1016/j.cytox.2020.100041

[4] Leishmaniasis in rheumatology, haematology and oncology: epidemiological, immunological and clinical aspects and caveats [J].

Bogdan, Christian .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 :60-66

[5] Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression [J].

Bosch-Nicolau, Pau ;

Ubals, Maria ;

Salvador, Fernando ;

Sanchez-Montalva, Adrian ;

Aparicio, Gloria ;

Erra, Alba ;

Martinez de Salazar, Pablo ;

Sulleiro, Elena ;

Molina, Israel .

PLOS NEGLECTED TROPICAL DISEASES, 2019, 13 (08)

[6]

Carvalhana S, 2016, J CLIN GASTROENTEROL, V50, P436, DOI 10.1097/MCG.0000000000000513

[7] Anti-Tumour Necrosis Factor-Induced Visceral and Cutaneous Leishmaniasis: Case Report and Review of the Literature [J].

Catala, Alba ;

Roe, Esther ;

Dalmau, Joan ;

Pomar, Virginia ;

Munoz, Carme ;

Yelamos, Oriol ;

Puig, Luis .

DERMATOLOGY, 2015, 230 (03) :204-207

[8] Cutaneous pseudolymphoma in association with Leishmania donovani [J].

Flaig, M. J. ;

Rupec, R. A. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (05) :1042-1043

[9] Clinical response to alimumab treatment in patients with moderate to severe psoriasis: Double-blind, randomized controlled trial and open-label extension study [J].

Gordon, Kenneth B. ;

Langley, Richard G. ;

Leonardi, Craig ;

Toth, Darryl ;

Menter, M. Alan ;

Kang, Sewon ;

Heffernan, Michael ;

Miller, Bruce ;

Hamlin, Regina ;

Lim, Liberata ;

Zhong, Jianhua ;

Hoffman, Rebecca ;

Okun, Martin M. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (04) :598-606

[10] Cutaneous pseudolymphoma induced by adalimumab and reproduced by infliximab in a patient with arthropathic psoriasis [J].

Imafuku, S. ;

Ito, K. ;

Nakayama, J. .

BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (03) :675-678

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