Novel polyamide based nucleic acid analogs - Synthesis of oligomers and RNA-binding properties

被引：13

作者：

GarciaEcheverria, C

Husken, D

Chiesi, CS

Altmann, KH

机构：

[1] CIBA, CENT RES LABS, FRIBOURG, SWITZERLAND

[2] CIBA, DEPT ONCOL, FRIBOURG, SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(97)00173-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of never polyamide based nucleic acid analogs incorporating monomer units of type I - III has been accomplished using solid-phase strategies based on N-delta-Fmoc protected building blocks. An oligomer composed of monomer units I exhibited weak, but sequence-specific RNA binding. Improved RNA-binding affinity was observed for analogs incorporating building blocks of type III with 2-(R) stereochemistry, but nor in the case of the 2-(S) isomers. (C) 1997 Elsevier Science Ltd.

引用

页码：1123 / 1126

页数：4

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[2]

Flory P. J., 1969, STAT MECH CHAIN MOL

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