Metals and Breast Cancer

被引：166

作者：

Byrne, Celia ^{[1
]}

Divekar, Shailaja D. ^{[2
,3
,4
]}

Storchan, Geoffrey B. ^{[2
,3
,4
]}

Parodi, Daniela A. ^{[2
,3
,4
]}

Martin, Mary Beth ^{[5
,6
,7
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA

[2] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

[3] Georgetown Univ, Dept Biochem, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

[4] Georgetown Univ, Dept Mol & Cellular Biol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

[5] Dept Oncol, Washington, DC USA

[6] Dept Biochem, Washington, DC USA

[7] Dept Mol & Cellular Biol, Washington, DC USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2013年 / 18卷 / 01期

关键词：

Estrogens; Estrogen receptor; Metalloestrogens; Metals; Endocrine disruptors; Breast cancer; ESTROGEN-RECEPTOR-ALPHA; LIGAND-BINDING DOMAIN; TOTAL DIET SAMPLES; ER-ALPHA; CADMIUM EXPOSURE; CELL-PROLIFERATION; SIGNALING PATHWAYS; STEROID-RECEPTORS; CRYSTAL-STRUCTURE; IN-VIVO;

D O I：

10.1007/s10911-013-9273-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-alpha. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.

引用

页码：63 / 73

页数：11

共 116 条

[1] Long-term dietary cadmium intake and postmenopausal endometrial cancer incidence:: A population-based prospective cohort study [J].