Peyronie's disease: Prevalence and association with cigarette smoking - A multicenter population-based study in men aged 50-69 years

被引:112
作者
La Pera, G
Pescatori, ES
Calabrese, M
Boffini, A
Colombo, F
Andriani, E
Natali, A
Vaggi, L
Catuogno, C
Giustini, M
Taggi, F
机构
[1] San Camillo Hosp, Rome, Italy
[2] Hesperia Hosp, Modena, Italy
[3] City Hosp, Avezzano, Italy
[4] San Giacomo Hosp, Rome, Italy
[5] Univ Milan, I-20122 Milan, Italy
[6] Univ Florence, I-50121 Florence, Italy
[7] Italian Natl Hlth Inst, Rome, Italy
关键词
Peyronie's disease (PD); prevalence; PD; risk factors; smoking; epidemiology; erectile dysfunction;
D O I
10.1159/000049830
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: We present a multicenter, population-based epidemiological survey aimed at assessing the prevalence of Peyronie's disease (PD) and its potential risk factors in the general population. Methods: In each of the ten centers throughout Italy, a uroandrologist contacted all the men in the age range 50-69 years registered with a general practitioner (GP). The subjects recruited were evaluated on the basis of their medical history, including alcohol consumption and cigarette smoking. The following questionnaires were administered: IIEF, IIPSS symptom score, premature ejaculation and PD. Results: All the subjects registered with a GP were invited to participate in the study. Of the 1,180 subjects, 647 (53%) entered over survey. In this population, 46 cases of PD were identified, accounting for a prevalence of 7.1%. The prevalence rate increased with age even if the trend is not statistically significant. The multivariate analysis showed a significant correlation between cigarette smoking and PD, with an odds ratio (OR) of 4.6 (CL 95%) confidence limit 1.506-14.287). Smoking as single variable had an OR of 7.2 (95% CL 2.34-24.93). No significant association was observed between PD and the other variables such as cardiovascular diseases, diabetes, hypertension and alcohol consumption. Conclusions: PD is a much more frequent condition in the general population than previously reported. According to our results, cigarette smoking may be considered a risk factor for developing PD. If further and more targeted studies confirm that giving up smoking may reduce the risk of developing PD, then there will be new prospects for primary and secondary prevention and for curbing the progression of the disease. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码:525 / 530
页数:6
相关论文
共 12 条
[1]   Smoking, alcohol and the risk of Dupuytren's contracture [J].
Burge, P ;
Hoy, G ;
Regan, P ;
Milne, R .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1997, 79B (02) :206-210
[2]   FACTORS ASSOCIATED IN THE ETIOLOGY OF PEYRONIES DISEASE [J].
CHILTON, CP ;
CASTLE, WM ;
WESTWOOD, CA ;
PRYOR, JP .
BRITISH JOURNAL OF UROLOGY, 1982, 54 (06) :748-750
[3]  
Çulha M, 1998, UROL INT, V60, P101
[4]  
GALLIZIA F, 1964, J Urol Nephrol (Paris), V70, P424
[5]   Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study [J].
Johannes, CB ;
Araujo, AB ;
Feldman, HA ;
Derby, CA ;
Kleinman, KP ;
McKinlay, JB .
JOURNAL OF UROLOGY, 2000, 163 (02) :460-463
[6]   THE INCIDENCE OF PEYRONIES DISEASE IN ROCHESTER, MINNESOTA, 1950 THROUGH 1984 [J].
LINDSAY, MB ;
SCHAIN, DM ;
GRAMBSCH, P ;
BENSON, RC ;
BEARD, CM ;
KURLAND, LT .
JOURNAL OF UROLOGY, 1991, 146 (04) :1007-1009
[7]   Etiologic factors in Peyronie's disease [J].
Muralidhar, S ;
Kumar, B ;
Sharma, SK ;
Sharma, M ;
Mandal, AK .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 1997, 36 (08) :579-581
[8]   Smoking in Italy, 1995 [J].
Pagano, R ;
La Vecchia, C ;
Decarli, A .
TUMORI, 1998, 84 (04) :456-459
[9]   Frequency and determinants of erectile dysfunction in Italy [J].
Parazzini, F ;
Fabris, FM ;
Bortolotti, A ;
Calabrò, A ;
Chatenoud, L ;
Colli, E ;
Landoni, M ;
Lavezzari, M ;
Turchi, P ;
Sessa, A ;
Vincenzo, M .
EUROPEAN UROLOGY, 2000, 37 (01) :43-48
[10]   The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction [J].
Rosen, RC ;
Riley, A ;
Wagner, G ;
Osterloh, IH ;
Kirkpatrick, J ;
Mishra, A .
UROLOGY, 1997, 49 (06) :822-830