Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell

被引：29
作者：
Chae, Hee-Sung [2 ]
Oh, Sei-Ryang [2 ]
Lee, Hyeong-Kyu [2 ]
Joo, Sang Hoon [3 ]
Chin, Young-Won [1 ]
机构：
[1] Dongguk Univ, Coll Pharm, Seoul 100715, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Immune Modulator Res Ctr, Biotherapeut Res Inst, Cheongwon Gun 363883, Chungbuk, South Korea
[3] Catholic Univ Daegu, Coll Pharm, Gyeongbuk 712702, South Korea
来源：
FOOD CHEMISTRY | 2012年 / 134卷 / 01期
关键词：
Garcinia Mangostana; alpha-Mangostin; gamma-Mangostin; Bone marrow derived mast cell; Interleukin-6; Prostaglandin D-2; Leukotriene C-4; Degranulation; Cyclooxygenase-2; Allergy; GARCINIA-MANGOSTANA; ACTIVATION;
D O I：
10.1016/j.foodchem.2012.02.075
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Mangosteen (Garcinia mangostana L), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, alpha-and gamma-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. alpha- and gamma-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D-2 (PGD(2)) and leukotriene C-4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, alpha- and gamma-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that alpha- and gamma-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：397 / 400
页数：4
相关论文
共 22 条
[1]   Plasma 9α, 11β-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma [J].
Bochenek, G ;
Nizankowska, E ;
Gielicz, A ;
Swierczynska, M ;
Szczeklik, A .
THORAX, 2004, 59 (06) :459-464
[2]   α-Mangostin, a Dietary Xanthone, Induces Autophagic Cell Death by Activating the AMP-Activated Protein Kinase Pathway in Glioblastoma Cells [J].
Chao, A-Ching ;
Hsu, Ya-Ling ;
Liu, Ching-Kuan ;
Kuo, Po-Lin .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (05) :2086-2096
[3]   Anti-inflammatory activity of mangostins from Garcinia mangostana [J].
Chen, Lih-Geeng ;
Yang, Ling-Ling ;
Wang, Ching-Chiung .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :688-693
[4]   Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement [J].
Chin, Young-Won ;
Kinghorn, A. Douglas .
MINI-REVIEWS IN ORGANIC CHEMISTRY, 2008, 5 (04) :355-364
[5]   LEUKOTRIENES PROMOTE PLASMA LEAKAGE AND LEUKOCYTE ADHESION IN POST-CAPILLARY VENULES - INVIVO EFFECTS WITH RELEVANCE TO THE ACUTE INFLAMMATORY RESPONSE [J].
DAHLEN, SE ;
BJORK, J ;
HEDQVIST, P ;
ARFORS, KE ;
HAMMARSTROM, S ;
LINDGREN, JA ;
SAMUELSSON, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3887-3891
[6]   Cyclooxygenase inhibitors - current status and future prospects [J].
Dannhardt, G ;
Kiefer, W .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (02) :109-126
[7]  
Farnsworth NR., 1992, THAI MED PLANTS RECO, P160
[8]   Cytotoxic Xanthone Constituents of the Stem Bark of Garcinia mangostana (Mangosteen) [J].
Han, Ah-Reum ;
Kim, Jeong-Ah ;
Lantvit, Daniel D. ;
Leonardus, B. S. Kardono ;
Riswan, Soedarsono ;
Chai, Heebyung ;
de Blanco, Esperanza J. Carcache ;
Farnsworth, Norman R. ;
Swanson, Steven M. ;
Kinghorn, A. Douglas .
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11) :2028-2031
[9]   Ethyl acetate extract of Psidium guajava']java inhibits IgE-mediated allergic responses by blocking FcεRI signaling [J].
Han, Eun Hee ;
Hwang, Yong Pil ;
Kim, Hyung Gyun ;
Park, Jin Hee ;
Choi, Jae Ho ;
Im, Ji Hye ;
Khanal, Tilak ;
Park, Bong Hwan ;
Yang, Ji Hye ;
Choi, Jun Min ;
Chun, Sung-Sik ;
Seo, Jong Kwon ;
Chung, Young Chul ;
Jeong, Hye Gwang .
FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (01) :100-108
[10]   Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen) [J].
Jung, HA ;
Su, BN ;
Keller, WJ ;
Mehta, RG ;
Kinghorn, AD .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (06) :2077-2082
123