Neuro-computational account of how mood fluctuations arise and affect decision making

被引：57

作者：

Vinckier, Fabien ^{[1
,2
,3
,4
,5
]}

Rigoux, Lionel ^{[1
,2
,6
,7
,8
]}

Oudiette, Delphine ^{[1
,2
,9
]}

Pessiglione, Mathias ^{[1
,2
]}

机构：

[1] Hop La Pitie Salpetriere, Inst Cerveau & Moelle Epiniere, Ctr NeuroImagerie Rech, Motivat Brain & Behav Lab, 47 Blvd Hop, F-75013 Paris, France

[2] Univ Pierre & Marie Curie UPMC Paris 6, CNRS U7225, Inserm U1127, Hop Pitie Salpetriere, 47 Blvd Hop, F-75013 Paris, France

[3] Ctr Hosp St Anne, Serv Hosp Univ, Dept Psychiat, 1 Rue Cabanis, F-75014 Paris, France

[4] Univ Paris Descartes Paris V, Sorbonne Paris Cite, 12 Rue Ecole Med, F-75006 Paris, France

[5] Ctr Psychiat & Neurosci, Inserm UMR S894, Lab Physiopathol Malad Psychiat, 1 Rue Alesia, F-75014 Paris, France

[6] Max Planck Inst Metab Res, Translat Neurocircuitry Grp, D-50931 Cologne, Germany

[7] Univ Zurich, Inst Biomed Engn, Translat Neuromodeling Unit, Wilfriedstr 6, CH-8032 Zurich, Switzerland

[8] ETH, Wilfriedstr 6, CH-8032 Zurich, Switzerland

[9] Hop La Pitie Salpetriere, Serv Pathol Sommeil, 47 Blvd Hop, F-75013 Paris, France

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

MAJOR DEPRESSIVE DISORDER; PREDICTION ERRORS; BIPOLAR DISORDER; VALUATION SYSTEM; RISK-TAKING; METAANALYSIS; BRAIN; ACTIVATION; REWARD; WELL;

D O I：

10.1038/s41467-018-03774-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The influence of mood on choices is a well-established but poorly understood phenomenon. Here, we suggest a three-fold neuro-computational account: (1) the integration of positive and negative events over time induce mood fluctuations, (2) which are underpinned by variations in the baseline activities of critical brain valuation regions, (3) which in turn modulate the relative weights assigned to key dimensions of choice options. We validate this model in healthy participants, using feedback in a quiz task to induce mood fluctuations, and a choice task (accepting vs. declining a motor challenge) to reveal their effects. Using fMRI, we demonstrate the pivotal role of the ventromedial prefrontal cortex and anterior insula, in which baseline activities respectively increase and decrease with theoretical mood level and respectively enhance the weighting of potential gains and losses during decision making. The same mechanisms might explain how decisions are biased in mood disorders at longer timescales.

引用

页数：12

共 71 条

[1] Neural Mechanisms Underlying Contextual Dependency of Subjective Values: Converging Evidence from Monkeys and Humans [J].