Osteoporosis drugs in real-world clinical practice: an analysis of persistence

被引：30

作者：

Iolascon, Giovanni ^{[1
]}

Gimigliano, Francesca ^{[1
]}

Orlando, Valentina ^{[2
]}

Capaldo, Annarita ^{[1
]}

Di Somma, Carolina ^{[3
]}

Menditto, Enrica ^{[2
]}

机构：

[1] Univ Naples 2, Dept Med & Surg Specialties & Dent, Naples, Italy

[2] Univ Naples Federico II, Dept Pharm, Ctr Pharmacoecon & Drug Utilizat CIRFF, Naples, Italy

[3] IRCCS, SDN Fdn, Naples, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2013年 / 25卷

关键词：

Osteoporosis; Persistence; Database; Drug utilization; ADHERENCE; THERAPY; FRACTURE; DETERMINANTS; POPULATION; MANAGEMENT;

D O I：

10.1007/s40520-013-0127-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The aim of our retrospective cohort study is to analyze the persistence rates in relation to antiosteoporotic drugs using administrative databases in the Campania Region. Patients, aged >= 40 years, were included if at least one prescription for any antiosteoporotic drugs had been filled in between January 1, 2009 and December 31, 2009. Overall, 37,594 patients were incident users of antiosteoporotic drugs. Among them, 15,978 patients had undergone spot-therapies. A total of 2,618 (14.1 %) were classified as switchers. Switching rates were highest for patients taking Alendronate 18.9 or Strontium Ranelate 15.0 and lower for patients taking Ibandronate 12.8 or Risedronate 10.8. In the overall population, 33.5 % of subjects were still on therapy after 6 months. At 1 year, persistence rates were: Ibandronate 21.6 %, Risedronate 15.8 %, Alendronate + Vitamin D 15.7 %, Raloxifene 14.3 %, Alendronate 12.6 % and Strontium Ranelate 5.0 %.

引用

页码：S137 / S141

页数：5

共 15 条

[1] Improving adherence in osteoporosis: a new management algorithm for the patient with osteoporosis [J].

Baio, Gianluca ;

Barbagallo, Mario ;

D'Avola, Giovanni ;

Di Luccio, Andrea ;

Di Tanna, Gian Luca ;

Falaschi, Paolo ;

Iolascon, Giovanni ;

Malavolta, Nazzarena ;

Robbiati, Federico ;

Ulivieri, Fabio Massimo .

EXPERT OPINION ON PHARMACOTHERAPY, 2011, 12 (02) :257-268

[2] Medication compliance and persistence: Terminology and definitions [J].

Cramer, Joyce A. ;

Roy, Anuja ;

Burrell, Anita ;

Fairchild, Carol J. ;

Fuldeore, Mahesh J. ;

Ollendorf, Daniel A. ;

Wong, Peter K. .

VALUE IN HEALTH, 2008, 11 (01) :44-47

[3] The burden of hospitalization related to diabetes mellitus: A population-based study [J].

De Berardis, G. ;

D'Ettorre, A. ;

Graziano, G. ;

Lucisano, G. ;

Pellegrini, F. ;

Cammarota, S. ;

Citarella, A. ;

Germinario, C. A. ;

Lepore, V. ;

Menditto, E. ;

Nicolosi, A. ;

Vitullo, F. ;

Nicolucci, A. .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2012, 22 (07) :605-612

[4] Fracture outcomes related to persistence and compliance with oral bisphosphonates [J].

Gallagher, Arlene M. ;

Rietbrock, Stephan ;

Olson, Melvin ;

van Staa, Tjeerd P. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (10) :1569-1575

[5] Assessment of compliance with osteoporosis treatment and its consequences in a managed care population [J].

Huybrechts, KF ;

Ishak, KJ ;

Caro, JJ .

BONE, 2006, 38 (06) :922-928

[6] Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: systematic review and meta-analysis [J].

Imaz, I. ;

Zegarra, P. ;

Gonzalez-Enriquez, J. ;

Rubio, B. ;

Alcazar, R. ;

Amate, J. M. .

OSTEOPOROSIS INTERNATIONAL, 2010, 21 (11) :1943-1951

[7] European guidance for the diagnosis and management of osteoporosis in postmenopausal women [J].

Kanis, J. A. ;

Burlet, N. ;

Cooper, C. ;

Delmas, P. D. ;

Reginster, J. -Y. ;

Borgstrom, F. ;

Rizzoli, R. .

OSTEOPOROSIS INTERNATIONAL, 2008, 19 (04) :399-428

[8] Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis [J].

Kothawala, Prajesh ;

Badamgarav, Enkhe ;

Ryu, Seonyoung ;

Miller, Ross M. ;

Halbert, R. J. .

MAYO CLINIC PROCEEDINGS, 2007, 82 (12) :1493-1501

[9] Incidence and costs of hip fractures compared to acute myocardial infarction in the Italian population: a 4-year survey [J].

Piscitelli, P. ;

Iolascon, G. ;

Gimigliano, F. ;

Muratore, M. ;

Camboa, P. ;

Borgia, O. ;

Forcina, B. ;

Fitto, F. ;

Robaud, V. ;

Termini, G. ;

Rini, G. B. ;

Gianicolo, E. ;

Faino, A. ;

Rossini, M. ;

Adami, S. ;

Angeli, A. ;

Distante, A. ;

Gatto, S. ;

Gimigliano, R. ;

Guida, G. .

OSTEOPOROSIS INTERNATIONAL, 2007, 18 (02) :211-219

[10] Low Incidence of Anti-Osteoporosis Treatment After Hip Fracture [J].

Rabenda, Veronique ;

Vanoverloop, Johan ;

Fabri, Valerie ;

Mertens, Raf ;

Sumkay, Francois ;

Vannccke, Carine ;

Deswaef, Andre ;

Verpooten, Gert A. ;

Reginster, Jean-Yves .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2008, 90A (10) :2142-2148

← 1 2 →