Function and molecular mechanism of tumor-targeted peptides for delivering therapeutic genes and chemical drugs

被引：9

作者：

Craig, Ryan ^{[1
]}

Li, Shulin ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 07期

关键词：

peptide; tumor-targeting; tumor vessel; gene therapy; gene delivery; drug delivery; adhesion molecule; phage display;

D O I：

10.2174/138955706777698615

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tumor-targeted chemo- or gene-therapies is a new form of treatment which provides the benefits of reducing systemic toxicity, increasing the tolerance, and enhancing therapeutic efficacy. This review will discuss the discovery, function, application, and mechanism by which the short peptides (5-9) work for tumor-targeted gene or drug delivery.

引用

页码：757 / 764

页数：8

共 96 条

[1] Therapeutic cancer targeting peptides [J].

Aina, OH ;

Sroka, TC ;

Chen, ML ;

Lam, KS .

BIOPOLYMERS, 2002, 66 (03) :184-199

[2] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[3] Steps toward mapping the human vasculature by phage display [J].

Arap, W ;

Kolonin, MG ;

Trepel, M ;

Lahdenranta, J ;

Cardó-Vila, M ;

Giordano, RJ ;

Mintz, PJ ;

Ardelt, PU ;

Yao, VJ ;

Vidal, CI ;

Chen, L ;

Flamm, A ;

Valtanen, H ;

Weavind, LM ;

Hicks, ME ;

Pollock, RE ;

Botz, GH ;

Bucana, CD ;

Koivunen, E ;

Cahill, D ;

Troncoso, P ;

Baggerly, KA ;

Pentz, RD ;

Do, KA ;

Logothetis, CJ ;

Pasqualini, R .

NATURE MEDICINE, 2002, 8 (02) :121-127

[4] Targeting the prostate for destruction through a vascular address [J].

Arap, W ;

Haedicke, W ;

Bernasconi, M ;

Kain, R ;

Rajotte, D ;

Krajewski, S ;

Ellerby, HM ;

Bredesen, DE ;

Pasqualini, R ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1527-1531

[5] Solution structures and integrin binding activities of an RGD peptide with two isomers [J].

Assa-Munt, N ;

Jia, X ;

Laakkonen, P ;

Ruoslahti, E .

BIOCHEMISTRY, 2001, 40 (08) :2373-2378

[6] Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis [J].

Bae, DG ;

Gho, YS ;

Yoon, WH ;

Chae, CB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (18) :13588-13596

[7] Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells [J].

Binder, RJ ;

Srivastava, PK .

NATURE IMMUNOLOGY, 2005, 6 (06) :593-599

[8] Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis [J].

Binétruy-Tournaire, R ;

Demangel, C ;

Malavaud, B ;

Vassy, R ;

Rouyre, S ;

Kraemer, M ;

Plouët, J ;

Derbin, C ;

Perret, G ;

Mazie, JC .

EMBO JOURNAL, 2000, 19 (07) :1525-1533

[9] Peptide aptamers: recent developments for cancer therapy [J].

Borghouts, C ;

Kunz, C ;

Groner, B .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2005, 5 (06) :783-797

[10] A novel approach for the identification of unique tumor vasculature binding peptides using an E-coli peptide display library [J].

Brown, CK ;

Modzelewski, RA ;

Johnson, CS ;

Wong, MKK .

ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (10) :743-749

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