Chemistry of Enaminonitriles of Pyrano[2,3-c]pyrazole and Related Compounds

被引:45
作者
Fadda, Ahmed A. [1 ]
El-Mekabaty, Ahmed [1 ]
Elattar, Khaled M. [2 ]
机构
[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt
[2] Sert Univ, Fac Sci, Dept Chem, Sert, Libya
关键词
Enaminonitriles; pyrano[2; 3-c]pyrazole; reactions; reactivity; synthesis; HETEROCYCLIC SYNTHESIS SYNTHESIS; MULTICOMPONENT REACTIONS; ONE-POT; ALPHA; BETA-ACETYLENIC ESTERS; S-TRIAZOLOPYRIMIDINES; 3-COMPONENT SYNTHESIS; SYNTHETIC UTILITY; PYRANOPYRAZOLES; DERIVATIVES; EFFICIENT;
D O I
10.1080/00397911.2012.744842
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This review highlights the methods used for the synthesis of enaminonitriles of pyrano[2,3-c]pyrazole compounds. Their reactivity and synthetic importance were investigated. In this context, recent progress in the synthesis and use of enaminonitriles of pyrano[2,3-c]pyrazole as precursors for heterocyclic compounds is reviewed. The synthetic routes for preparation of enaminonitriles are based on multicomponent reactions including three- or four-component reactions. Enaminonitriles can be used as building blocks for carbocyclic five-, six-, and seven-membered heterocycles as well as fused heterocyclic compounds. The bibliography includes 94 references.
引用
收藏
页码:2685 / 2719
页数:35
相关论文
共 90 条
[11]   Rapid One-pot, Four Component Synthesis of Pyranopyrazoles Using Heteropolyacid Under Solvent-free Condition [J].
Chavan, Hemant V. ;
Babar, Santosh B. ;
Hoval, Rahul U. ;
Bandgar, Babasaheb P. .
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (11) :3963-3966
[12]   Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction [J].
Chebanov, VA ;
Muravyova, EA ;
Desenko, SM ;
Musatov, VI ;
Knyazeva, IV ;
Shishkina, SV ;
Shishkin, OV ;
Kappe, CO .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2006, 8 (03) :427-434
[13]  
Dandia A, 2003, HETEROCYCL COMMUN, V9, P415
[14]   Recent developments in isocyanide based multicomponent reactions in applied chemistry [J].
Dömling, A .
CHEMICAL REVIEWS, 2006, 106 (01) :17-89
[15]   Recent advances in isocyanide-based multicomponent chemistry [J].
Dömling, A .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :306-313
[16]  
Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO
[17]  
2-U
[18]   Three-component Biginelli cyclocondensation reaction using C-glycosylated substrates.: Preparation of a collection of dihydropyrimidinone glycoconjugates and the synthesis of C-glycosylated monastrol analogues [J].
Dondoni, A ;
Massi, A ;
Sabbatini, S ;
Bertolasi, V .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (20) :6979-6994
[19]   Synthesis of 4-alkyl(aryl, hetaryl)-2-thioxo-5,6,7,8-tetrahydroquinoline-3-carbonitriles and their derivatives by cross-recyclization of 4-alkyl(aryl, hetaryl)-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles with 4-(cyclohex-1-en-1-yl)-morpholine, alkyl halides, and cyclohexanone [J].
Dyachenko, V. D. ;
Dyachenko, A. D. .
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 44 (03) :412-420
[20]  
El-Assiery Saied Abdullah, 2004, Acta Pharmaceutica (Zagreb), V54, P143