Live Imaging of Innate and Adaptive Immune Responses in the Liver

被引：20

作者：

Li, Lu ^{[1
,2
]}

Zeng, Zhutian ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Hefei, Peoples R China

[2] Univ Sci & Technol China, Sch Basic Med Sci, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Innate Immun & Chron Dis,Div Life Sci, Hefei, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

intravital imaging; Kupffer cell; iNKT cell; NK cell; T cells; infection; liver disease; CD8(+) T-CELLS; MONOCYTE-DERIVED MACROPHAGES; CIRCULATING TUMOR-CELLS; RESIDENT NK CELLS; KUPFFER CELLS; IMMUNOLOGICAL-TOLERANCE; NEUTROPHIL RECRUITMENT; SPATIAL RECONSTRUCTION; INFLAMED LIVER; CANCER-CELLS;

D O I：

10.3389/fimmu.2020.564768

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune response in the liver is determined by the spatial organization and cellular dynamics of hepatic immune cells. The liver vasculature accommodates abundant tissue-resident innate immune cells, such as Kupffer cells, natural killer cells, and natural killer T cells, to ensure efficient intravascular immunosurveillance. The fenestrated sinusoids also allow direct contact between circulating T cells and non-canonical antigen-presenting cells, such as hepatocytes, to instruct adaptive immune responses. Distinct cellular behaviors are exploited by liver immune cells to exert proper functions. Intravital imaging enables real-time visualization of individual immune cell in living animals, representing a powerful tool in dissecting the spatiotemporal features of intrahepatic immune cells during steady state and liver diseases. This review summarizes current advances in liver immunology prompted byin vivoimaging, with a particular focus on liver-resident innate immune cells and hepatic T cells.

引用

页数：14

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