Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids

被引：60

作者：

Chen, Lijun ^{[1
]}

Ju, Lin ^{[1
]}

Bustin, Katelyn A. ^{[1
]}

Hoover, Jessica M. ^{[1
]}

机构：

[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 81期

基金：

美国国家科学基金会;

关键词：

CARBON-HYDROGEN BONDS; AROMATIC CARBOXYLIC-ACIDS; BENZOIC-ACIDS; COUPLING REACTIONS; BIARYL SYNTHESIS; CUPROUS CARBOXYLATES; ARYL FLUORIDES; ACTIVATION; HALIDES; FUNCTIONALIZATION;

D O I：

10.1039/c5cc06645j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.

引用

页码：15059 / 15062

页数：4

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