Lipofuscin: formation, effects and role of macroautophagy

被引：209

作者：

Hoehn, Annika ^{[1
]}

Grune, Tilman ^{[1
]}

机构：

[1] Univ Jena, Inst Nutr, Dept Nutr Toxicol, D-07743 Jena, Germany

来源：

REDOX BIOLOGY | 2013年 / 1卷 / 01期

关键词：

Aging; Oxidative stress; Proteasome; Lipofuscin; Autophagy;

D O I：

10.1016/j.redox.2013.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked unclegradable aggregates such as lipoluscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed. (C) 2013 The Authors. Published by Elsevier B.V. Open access under CC BY-NC-ND license.

引用

页码：140 / 144

页数：5

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