Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide A

被引：14

作者：

Rubio, Brent K. ^{[1
,2
]}

Robinson, Sarah J. ^{[1
,2
]}

Avalos, Claudia E. ^{[1
,2
]}

Valeriote, Frederick A. ^{[3
]}

de Voogd, Nicole J. ^{[4
]}

Crews, Phillip ^{[1
,2
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

[3] Henry Ford Hlth Syst, Josephine Ford Canc Ctr, Detroit, MI 48202 USA

[4] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 08期

关键词：

D O I：

10.1021/np800230d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S. 7S, 11S, 14S.

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页码：1475 / 1478

页数：4

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