pH-Independent Transfer Hydrogenation in Water: Catalytic, Enantioselective Reduction of β-Keto Esters

被引：40
作者：
Ariger, Martin A. [1 ]
Carreira, Erick M. [1 ]
机构：
[1] Swiss Fed Inst Technol, Organ Chem Lab, Hongg, Switzerland
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 17期
基金：
瑞士国家科学基金会;
关键词：
ASYMMETRIC TRANSFER HYDROGENATION; DEPENDENT TRANSFER HYDROGENATION; SOLUBLE CARBONYL-COMPOUNDS; RU-TSDPEN CATALYSTS; IRIDIUM HYDRIDE; CP-ASTERISK; ALCOHOLS; CYCLOPROPANATION; HYDROCHLORIDE; AMINATION;
D O I：
10.1021/ol301903c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A pH-independent asymmetric transfer hydrogenation of beta-keto esters in water with formic acid/sodium formate is described. The reaction is conducted open to air and gives access to p-hydroxy esters in excellent yields and selectivities.
引用
收藏
页码：4522 / 4524
页数：3
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