pH-Independent Transfer Hydrogenation in Water: Catalytic, Enantioselective Reduction of β-Keto Esters

被引：40

作者：

Ariger, Martin A. ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Organ Chem Lab, Hongg, Switzerland

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 17期

基金：

瑞士国家科学基金会;

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; DEPENDENT TRANSFER HYDROGENATION; SOLUBLE CARBONYL-COMPOUNDS; RU-TSDPEN CATALYSTS; IRIDIUM HYDRIDE; CP-ASTERISK; ALCOHOLS; CYCLOPROPANATION; HYDROCHLORIDE; AMINATION;

D O I：

10.1021/ol301903c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pH-independent asymmetric transfer hydrogenation of beta-keto esters in water with formic acid/sodium formate is described. The reaction is conducted open to air and gives access to p-hydroxy esters in excellent yields and selectivities.

引用

页码：4522 / 4524

页数：3

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