共 49 条
Bortezomib sensitizes thyroid cancer to BRAF inhibitor in vitro and in vivo
被引:27
作者:

Tsumagari, Koji
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机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Abd Elmageed, Zakaria Y.
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h-index: 0
机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Sholl, Andrew B.
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h-index: 0
机构:
Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Green, Erik A.
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机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Sobti, Saboori
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机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Khan, Abdul Razzaq
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Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Kandil, Abdulrahman
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Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

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Friedlander, Paul
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机构:
Tulane Univ, Sch Med, Dept Otolaryngol, 1430 Tulane Ave, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Boulares, A. Hamid
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h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Stanley Scott Canc Ctr, New Orleans, LA USA
Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Kandil, Emad
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
Tulane Univ, Sch Med, Dept Otolaryngol, 1430 Tulane Ave, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
机构:
[1] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA
[3] Tulane Univ, Sch Med, Dept Otolaryngol, 1430 Tulane Ave, New Orleans, LA 70112 USA
[4] Louisiana State Univ, Hlth Sci Ctr, Stanley Scott Canc Ctr, New Orleans, LA USA
[5] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA USA
关键词:
BRAFV600E;
NF-kappa B;
thyroid cancer;
Vemurafenib;
Bortezomib;
INTENSITY FOCUSED ULTRASOUND;
RADIOFREQUENCY THERMAL ABLATION;
DOUBLE-BLIND;
THERAPY;
NODULES;
CARCINOMA;
PAPILLARY;
MELANOMA;
MANAGEMENT;
MECHANISM;
D O I:
10.1530/ERC-17-0182
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Although overall survival rate for patients with thyroid cancer (TC) is high, there is an alarming 10-year recurrence rate of up to 30% conferring a similar to 50% survival among these high-risk patients. The BRAFV600E mutation is estimated to be present in over 50% of papillary thyroid cancer (PTC) cases besides being associated with carcinogenesis and poor prognosis. We assessed the status of NF-kappa B, Ki-67, cyclin D1 and BRAFV600E in TC tissues and TC cell lines using immunohistochemistry and Western blot analysis. Concurrently, we evaluated the outcomes of combined targeting of the proteasome pathway in addition to selective BRAF inhibitors in cases of PTC. In this study, BRAFV600E-bearing TC cells were treated with BRAFV600E inhibitor, Vemurafenib alone or in combination with the proteasome inhibitor, Bortezomib. The combination of both drugs showed synergistic effects as evidenced by cell growth inhibition (P < 0.05), increased G2-phase cell cycle arrest and induced apoptosis (P < 0.05). In our TC xenograft model, the combination of Vemurafenib and Bortezomib significantly reduced tumor size (P < 0.05) and expression of the markers of cell growth and proliferation, Ki-67 and cyclin D1 (P < 0.001), when compared to monotherapy. Further analysis demonstrated that treatment with Bortezomib sensitized TC cells to Vemurafenib via mitochondrial dysregulation and apoptosis of TC cells, as evidenced by the increase in the expression of p53, Noxa protein, the loss of mitochondrial membrane potential, cytochrome c release and Poly (ADP-ribose) polymerase cleavage. Our results demonstrate a strong clinical potential for the combination of the Bortezomib and the BRAF inhibitor Vemurafenib as an efficient therapeutic approach for the treatment of TC.
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页码:99 / 109
页数:11
相关论文
共 49 条
[1]
Immunohistochemistry as an accurate tool for evaluating BRAF-V600E mutation in 130 samples of papillary thyroid cancer
[J].
Abd Elmageed, Zakaria Y.
;
Sholl, Andrew B.
;
Tsumagari, Koji
;
Al-Qurayshi, Zaid
;
Basolo, Fulvio
;
Moroz, Krzysztof
;
Boulares, A. Hamid
;
Friedlander, Paul
;
Miccoli, Paulo
;
Kandil, Emad
.
SURGERY,
2017, 161 (04)
:1122-1128

Abd Elmageed, Zakaria Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
Tulane Univ, Sch Med, Dept Otolaryngol, 1430 Tulane Ave, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Sholl, Andrew B.
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Tsumagari, Koji
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

论文数: 引用数:
h-index:
机构:

Basolo, Fulvio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pisa, Dept Surg Med Mol & Crit Area Pathol, Pisa, Italy Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Moroz, Krzysztof
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Boulares, A. Hamid
论文数: 0 引用数: 0
h-index: 0
机构:
LSU Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Friedlander, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Otolaryngol, 1430 Tulane Ave, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Miccoli, Paulo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pisa, Dept Surg Med Mol & Crit Area Pathol, Pisa, Italy Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

Kandil, Emad
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
[2]
Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro
[J].
Bailey, MR
;
Couret, LN
;
Sapozhnikov, OA
;
Khokhlova, VA
;
Ter Haar, G
;
Vaezy, S
;
Shi, XG
;
Martin, R
;
Crum, LA
.
ULTRASOUND IN MEDICINE AND BIOLOGY,
2001, 27 (05)
:695-708

Bailey, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Couret, LN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Sapozhnikov, OA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Khokhlova, VA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Ter Haar, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Vaezy, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Shi, XG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Martin, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA

Crum, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA
[3]
High-Intensity Focussed Ultrasound in Low-Risk Prostate Cancer - Oncological Outcome and Postinterventional Quality of Life of an Inexperienced Therapy Centre in Comparison with an Experienced Therapy Centre
[J].
Baumunk, D.
;
Andersen, C.
;
Heile, U.
;
Ebbing, J.
;
Cash, H.
;
Porsch, M.
;
Liehr, U. -B.
;
Janitzky, A.
;
Wendler, J. J.
;
Schindele, D.
;
Blaschke, S.
;
Miller, K.
;
Schostak, M.
.
AKTUELLE UROLOGIE,
2013, 44 (04)
:285-292

Baumunk, D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Andersen, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Urol Klin, D-13353 Berlin, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Heile, U.
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Urol Klin, D-13353 Berlin, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Ebbing, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Urol Klin, D-13353 Berlin, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Cash, H.
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Urol Klin, D-13353 Berlin, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Porsch, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Liehr, U. -B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Janitzky, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Wendler, J. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Schindele, D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Blaschke, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Miller, K.
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Urol Klin, D-13353 Berlin, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany

Schostak, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany Univ Klinikum Magdeburg AoR, Klin & Poliklin Urol & Kinderurol, D-39120 Magdeburg, Germany
[4]
Percutaneous ethanol injection therapy in benign solitary solid cold thyroid nodules:: A randomized trial comparing one injection with three injections
[J].
Bennedbæk, FN
;
Hegedüs, L
.
THYROID,
1999, 9 (03)
:225-233

Bennedbæk, FN
论文数: 0 引用数: 0
h-index: 0
机构:
Odense Univ Hosp, Dept Endocrinol, Odense C, Denmark Odense Univ Hosp, Dept Endocrinol, Odense C, Denmark

Hegedüs, L
论文数: 0 引用数: 0
h-index: 0
机构:
Odense Univ Hosp, Dept Endocrinol, Odense C, Denmark Odense Univ Hosp, Dept Endocrinol, Odense C, Denmark
[5]
Treatment of recurrent thyroid cysts with ethanol:: A randomized double-blind controlled trial
[J].
Bennedbæk, FN
;
Hegedüs, L
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
2003, 88 (12)
:5773-5777

Bennedbæk, FN
论文数: 0 引用数: 0
h-index: 0
机构:
Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark

Hegedüs, L
论文数: 0 引用数: 0
h-index: 0
机构:
Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark
[6]
Vemurafenib: the first drug approved for BRAF-mutant cancer
[J].
Bollag, Gideon
;
Tsai, James
;
Zhang, Jiazhong
;
Zhang, Chao
;
Ibrahim, Prabha
;
Nolop, Keith
;
Hirth, Peter
.
NATURE REVIEWS DRUG DISCOVERY,
2012, 11 (11)
:873-886

Bollag, Gideon
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Tsai, James
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Zhang, Jiazhong
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Zhang, Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Ibrahim, Prabha
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Nolop, Keith
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA

Hirth, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon, Berkeley, CA 94710 USA Plexxikon, Berkeley, CA 94710 USA
[7]
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial
[J].
Brose, Marcia S.
;
Nutting, Christopher M.
;
Jarzab, Barbara
;
Elisei, Rossella
;
Siena, Salvatore
;
Bastholt, Lars
;
de la Fouchardiere, Christelle
;
Pacini, Furio
;
Paschke, Ralf
;
Shong, Young Kee
;
Sherman, Steven I.
;
Smit, Johannes W. A.
;
Chung, John
;
Kappeler, Christian
;
Pena, Carol
;
Molnar, Istvan
;
Schlumberger, Martin J.
.
LANCET,
2014, 384 (9940)
:319-328

Brose, Marcia S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Nutting, Christopher M.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Marsden Hosp, London SW3 6JJ, England Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Jarzab, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Maria Sklodowska Curie Mem Canc Ctr, Gliwice, Poland
Inst Oncol, Gliwice, Poland Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Elisei, Rossella
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pisa, Dept Clin & Expt Med, Pisa, Italy Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Siena, Salvatore
论文数: 0 引用数: 0
h-index: 0
机构:
Osped Niguarda Ca Granda, Niguarda Canc Ctr, Milan, Italy Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Bastholt, Lars
论文数: 0 引用数: 0
h-index: 0
机构:
Odense Univ Hosp, Dept Oncol, DK-5000 Odense C, Denmark Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

de la Fouchardiere, Christelle
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Civils, Ctr Anticanc, Consortium Canc Thyroidien, Lyon, France Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Pacini, Furio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Siena, Unit Endocrinol, I-53100 Siena, Italy Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Paschke, Ralf
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leipzig, Dept Endocrinol & Nephrol, D-04109 Leipzig, Germany Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Shong, Young Kee
论文数: 0 引用数: 0
h-index: 0
机构:
Asan Med Ctr, Div Endocrinol, Seoul, South Korea Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Sherman, Steven I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Smit, Johannes W. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Chung, John
论文数: 0 引用数: 0
h-index: 0
机构:
Bayer HealthCare Pharmaceut, Whippany, NJ USA Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Kappeler, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Bayer Pharma AG, Berlin, Germany Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Pena, Carol
论文数: 0 引用数: 0
h-index: 0
机构:
Bayer HealthCare Pharmaceut, Whippany, NJ USA Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Molnar, Istvan
论文数: 0 引用数: 0
h-index: 0
机构:
Bayer HealthCare Pharmaceut, Whippany, NJ USA Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

Schlumberger, Martin J.
论文数: 0 引用数: 0
h-index: 0
机构:
Gustave Roussy, Villejuif, France
Univ Paris 11, Villejuif, France Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
[8]
Activating BRAF and PIK3CA Mutations Cooperate to Promote Anaplastic Thyroid Carcinogenesis
[J].
Charles, Roch-Philippe
;
Silva, Jillian
;
Iezza, Gioia
;
Phillips, Wayne A.
;
McMahon, Martin
.
MOLECULAR CANCER RESEARCH,
2014, 12 (07)
:979-986

Charles, Roch-Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Cell & Mol Pharmacol, San Francisco, CA 94143 USA Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

Silva, Jillian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Cell & Mol Pharmacol, San Francisco, CA 94143 USA Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

Iezza, Gioia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

Phillips, Wayne A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Sir Peter MacCallum Canc Ctr, Surg Oncol Lab, Melbourne, Vic 3010, Australia Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

McMahon, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Cell & Mol Pharmacol, San Francisco, CA 94143 USA Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
[9]
BRAF-Mutated Colorectal Cancer: What Is the Optimal Strategy for Treatment?
[J].
Cohen, Romain
;
Cervera, Pascale
;
Svrcek, Magali
;
Pellat, Anna
;
Dreyer, Chantal
;
de Gramont, Aimery
;
Andre, Thierry
.
CURRENT TREATMENT OPTIONS IN ONCOLOGY,
2017, 18 (02)

Cohen, Romain
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

Cervera, Pascale
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

Svrcek, Magali
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

Pellat, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

Dreyer, Chantal
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

de Gramont, Aimery
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Hosp Franco Britannique, Dept Med Oncol, 4 Kleber, F-92300 Levallois Perret, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France

Andre, Thierry
论文数: 0 引用数: 0
h-index: 0
机构:
St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France
GERCOR, Oncol Multidisciplinary Grp, 151 Faubourg St Antoine, F-75011 Paris, France St Antoine Hosp, AP HP, Dept Med Oncol, 184 Faubourg St Antoine, F-75012 Paris, France
[10]
Efficacy and Tolerability of Vemurafenib in Patients with BRAFV600E -Positive Papillary Thyroid Cancer: MD Anderson Cancer Center Off Label Experience
[J].
Dadu, Ramona
;
Shah, Komal
;
Busaidy, Naifa L.
;
Waguespack, Steven G.
;
Habra, Mouhammad A.
;
Ying, Anita K.
;
Hu, Mimi I.
;
Bassett, Roland
;
Jimenez, Camilo
;
Sherman, Steven I.
;
Cabanillas, Maria E.
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
2015, 100 (01)
:E77-E81

Dadu, Ramona
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Shah, Komal
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Busaidy, Naifa L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Waguespack, Steven G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Habra, Mouhammad A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Ying, Anita K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Hu, Mimi I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Bassett, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Jimenez, Camilo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Sherman, Steven I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

Cabanillas, Maria E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA