Kadpolysperins A-N, lanostane triterpene acids possessing rich structure types from Kadsura polysperma

被引：22

作者：

Dong, Ke ^{[1
,2
]}

Pu, Jian-Xin ^{[1
]}

Du, Xue ^{[1
]}

Su, Jia ^{[1
]}

Li, Xiao-Nian ^{[1
]}

Yang, Jian-Hong ^{[1
]}

Zhao, Wei ^{[3
]}

Li, Yan ^{[1
]}

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Yunnan Acad Tobacco Sci, Kunming 650106, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 24期

关键词：

Kadsura polysperma; Lanostane triterpene acid; Kadpolysperins; Cytotoxicity; LIGNANS; DILACTONES; STEMS; LACTONES; INTERIOR;

D O I：

10.1016/j.tet.2012.03.116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fourteen new lanostane triterpene acids (1-14), and five known analogues (15-19) were isolated from the stems of Kadsura polysperma. Compound 1, with a rearranged tetracyclic skeleton, is an important biogenic precursor of longipedlactone skeleton. Compounds 2-6 are members of 18(13 -> 12)-abeo-lanostane triterpene acids. The structures of new compounds were elucidated by spectroscopic evidence. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4820 / 4829

页数：10

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