Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer

被引：37

作者：

Nakashima, Hiroshi ^{[1
]}

Natsugoe, Shoji ^{[1
]}

Ishigami, Sumiya ^{[1
]}

Okumura, Hiroshi ^{[1
]}

Matsumoto, Masataka ^{[1
]}

Hokita, Shuichi ^{[1
]}

Aikou, Takashi ^{[1
]}

机构：

[1] Kagoshima Univ, Dept Surg Oncol & Digest Surg, Field Oncol, Course Adv Therapeut,Grad Sch Med & Dent Sci, Kagoshima 8908520, Japan

来源：

CANCER LETTERS | 2006年 / 236卷 / 01期

关键词：

spleen tyrosine kinase; gastric cancer; tumor suppressor; lymph node metastasis;

D O I：

10.1016/j.canlet.2005.05.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spleen tyrosine kinase (Syk) expression was immunohistochemically examined in 250 gastric cancer patients. The rate of positive Syk expression was 42.4%. Syk expression was significantly associated with T1 tumors, lymphatic invasion, venous invasion and lymph node metastasis (P < 0.0001). The 5-year survival rate was significantly higher among patients with nuclear Syk expression than among those who were negative for Syk expression (P = 0.0003). However, Syk expression was not an independent prognostic factor. Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：89 / 94

页数：6

共 19 条

[1] Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk [J].