Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition

被引：7

作者：

Amen, Triana ^{[1
]}

Kaganovich, Daniel ^{[1
,2
]}

机构：

[1] Univ Med Ctr Goettingen, Dept Expt Neurodegenerat, D-37073 Gottingen, Germany

[2] 1Base Pharmaceut, Boston, MA 02129 USA

来源：

ISCIENCE | 2020年 / 23卷 / 10期

基金：

欧洲研究理事会;

关键词：

TRANSLATION INITIATION; ANTITUMOR-ACTIVITY; INTERACTING PROTEINS; PHASE-TRANSITION; APOPTOSIS; PROTEOME; PATHWAY; SEQUESTRATION; PLATFORM; KINASE;

D O I：

10.1016/j.isci.2020.101550

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid synthase inhibition, characterized by high internal mobility and rapid turnover.

引用

页数：18

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