Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it

被引：74

作者：

Mirhoseini, Ali ^{[1
]}

Amani, Jafar ^{[1
]}

Nazarian, Shahram ^{[2
]}

机构：

[1] Baqiyatallah Univ Med Sci, Appl Microbiol Res Ctr, Syst Biol & Poisonings Inst, Tehran, Iran

[2] Imam Hossein Univ, Dept Biol, Tehran, Iran

来源：

MICROBIAL PATHOGENESIS | 2018年 / 117卷

关键词：

Intestinal pathogenic; Enterotoxigenic Escherichia colt; Virulence factors; Mucosal immunity; Vaccine; HEAT-LABILE ENTEROTOXIN; COLONIZATION-FACTOR; B-SUBUNIT; DEVELOPING-COUNTRIES; CHOLERA-TOXIN; STABLE STA; ETEC; IMMUNOGENICITY; PROTEIN; ANTIGEN;

D O I：

10.1016/j.micpath.2018.02.032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterotoxigenic Escherichia coli (ETEC) is the most common cause of diarrhea in children. Colonization factors (CFs) and LT enterotoxin are the major ETEC candidate vaccines. To cause disease, ETEC must adhere to the epithelium of the small intestine by means of CFs. Watery diarrhea is produced due to the effects of the enterotoxins. Vaccine development against ETEC has been identified as an important primary prevention strategy in developing countries and for travelers to these regions. Mucosal immunization can cause secretory IgA antibody (sIgA) responses that prevents the attachment of bacteria to the intestine and are of particular importance for provide protection against ETEC infection. The design of multivalent ETEC vaccine containing various colonization factors and ETEC toxin may provide protection against a wide range of bacterial strains. In this review, the importance and pathogenesis of ETEC, and the latest ETEC vaccine research results are discussed.

引用

页码：162 / 169

页数：8