Synthesis and Antimicrobial Evaluation of Thieno[2,3-d]-pyrimidine, Thieno [2′,3′:4,5]pyrimido [1,2-a][1,3,5]triazine, Thieno[2,3-d]-1,3-thiazine and 1,2,4-Triazole Systems

被引：18

作者：

Hemdan, Magdy Mohamed ^{[1
]}

El-Mawgoude, Heba Kamal Abd ^{[2
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt

[2] Ain Shams Univ, Fac Women, Dept Chem, Cairo 11767, Egypt

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2015年 / 63卷 / 10期

关键词：

fused 1,3-diazine; fused 1,3-thiazine; 1,2,4-triazole; lauroyl isothiocyanate; 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; PYRIMIDINE-DERIVATIVES; FUSED PYRIMIDINES; ISOTHIOCYANATE; CYCLIZATION; AGENTS;

D O I：

10.1248/cpb.c15-00463

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of lauroyl isothiocyanate with ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate gave ethyl 2-(3-dodecanoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 3. Compound 3 could serve as a main building block in synthesis of the target heterocyclic systems like thieno[2,3-d]-pyrimidine, thieno[2',3':4,5]pyrimido[1,2-a][1,3,5]triazine, thieno[2,3-d]-1,3-thiazine and 1,2,4-triazole systems attached to the lauryl group. The structures of the synthesized target heterocyclic compounds were confirmed by microanalytical and spectral data. The antimicrobial activity of some of the synthesized compounds was tested.

引用

页码：812 / 818

页数：7

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