Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway

被引：94

作者：

Pietsch, Torsten ^{[1
]}

Wohlers, Inken ^{[2
]}

Goschzik, Tobias ^{[1
]}

Dreschmann, Verena ^{[1
]}

Denkhaus, Dorota ^{[1
]}

Doerner, Evelyn ^{[1
]}

Rahmann, Sven ^{[2
,3
]}

Klein-Hitpass, Ludger ^{[4
]}

机构：

[1] Univ Bonn, Dept Neuropathol, D-53105 Bonn, Germany

[2] Univ Duisburg Essen, Univ Hosp Essen, Inst Human Genet, D-45122 Essen, Germany

[3] Univ Duisburg Essen, Ctr Med Biotechnol, D-45122 Essen, Germany

[4] Univ Duisburg Essen, Med Ctr, Dept Cell Biol Tumor Reserach, D-45122 Essen, Germany

来源：

ACTA NEUROPATHOLOGICA | 2014年 / 127卷 / 04期

关键词：

INFLAMMATION;

D O I：

10.1007/s00401-014-1264-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：609 / 611

页数：3

共 9 条

[1] Mutations in the NF-κB signaling pathway:: implications for human disease [J].

Courtois, G. ;

Gilmore, T. D. .

ONCOGENE, 2006, 25 (51) :6831-6843

[2] NF-κB and the link between inflammation and cancer [J].

DiDonato, Joseph A. ;

Mercurio, Frank ;

Karin, Michael .

IMMUNOLOGICAL REVIEWS, 2012, 246 :379-400

[3] Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases [J].

Flucke, Uta ;

Tops, Bastiaan B. J. ;

Somerhausen, Nicolas de Saint Aubain ;

Bras, Johannes ;

Creytens, David H. ;

Kusters, Benno ;

Groenen, Patricia J. T. A. ;

Verdijk, Marian A. J. ;

Suurmeijer, Albert J. H. ;

Mentzel, Thomas .

HISTOPATHOLOGY, 2013, 62 (06) :925-930

[4] The complexity of NF-κB signaling in inflammation and cancer [J].

Hoesel, Bastian ;

Schmid, Johannes A. .

MOLECULAR CANCER, 2013, 12

[5] C11 orf95-MKL2 Is the Resulting Fusion Oncogene of t(11;16)(q13;p13) in Chondroid Lipoma [J].

Huang, Dali ;

Sumegi, Janos ;

Dal Cin, Paola ;

Reith, John D. ;

Yasuda, Taketoshi ;

Nelson, Marilu ;

Muirhead, David ;

Bridge, Julia A. .

GENES CHROMOSOMES & CANCER, 2010, 49 (09) :810-818

[6]

McLendon R E., 2007, WHO Classification of Tumours of the Central Nervous System, P74

[7] Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing [J].

Pflueger, Dorothee ;

Terry, Stephane ;

Sboner, Andrea ;

Habegger, Lukas ;

Esgueva, Raquel ;

Lin, Pei-Chun ;

Svensson, Maria A. ;

Kitabayashi, Naoki ;

Moss, Benjamin J. ;

MacDonald, Theresa Y. ;

Cao, Xuhong ;

Barrette, Terrence ;

Tewari, Ashutosh K. ;

Chee, Mark S. ;

Chinnaiyan, Arul M. ;

Rickman, David S. ;

Demichelis, Francesca ;

Gerstein, Mark B. ;

Rubin, Mark A. .

GENOME RESEARCH, 2011, 21 (01) :56-67

[8] Radial glia cells are candidate stem cells of ependymoma [J].

Taylor, MD ;

Poppleton, H ;

Fuller, C ;

Su, XP ;

Liu, YX ;

Jensen, P ;

Magdaleno, S ;

Dalton, J ;

Calabrese, C ;

Board, J ;

MacDonald, T ;

Rutka, J ;

Guha, A ;

Gajjar, A ;

Curran, T ;

Gilbertson, RJ .

CANCER CELL, 2005, 8 (04) :323-335

[9] Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma [J].

Xie, Tong-Xin ;

Xia, Zhibo ;

Zhang, Nu ;

Gong, Weida ;

Huang, Suyun .

ONCOLOGY REPORTS, 2010, 23 (03) :725-732

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