Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria

被引：228

作者：

Schrader, Jens ^{[1
]}

Schilling, Martin ^{[1
]}

Holtmann, Dirk ^{[1
]}

Sell, Dieter ^{[1
]}

Villela Filho, Murillo ^{[2
]}

Marx, Achim ^{[2
]}

Vorholt, Julia A. ^{[3
]}

机构：

[1] DECHEMA eV, Karl Winnacker Inst, Biochem Engn, D-60486 Frankfurt, Germany

[2] Evon Degussa GmbH, Sci Business Ctr Biotechnol, D-45772 Marl, Germany

[3] Swiss Fed Inst Technol, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 2009年 / 27卷 / 02期

关键词：

METHYLOBACTERIUM-EXTORQUENS AM1; POLY-BETA-HYDROXYBUTYRATE; SINGLE-CELL PROTEIN; L-SERINE PRODUCTION; L-LYSINE PRODUCTION; FED-BATCH CULTURE; METHYLOPHILUS-METHYLOTROPHUS; BACILLUS-METHANOLICUS; METHYLOBACILLUS-FLAGELLATUS; FORMALDEHYDE OXIDATION;

D O I：

10.1016/j.tibtech.2008.10.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Methanol is one of the building blocks in the chemical industry and can be synthesized either from petrochemical or renewable resources, such as biogas. Bioprocess technology with methylotrophic bacteria is well established, as illustrated by large-scale single-cell protein production in the past. During recent years, the first genomes of methylotrophs have been sequenced and significant progress in elucidating their metabolism has been made. In addition, the tool set for genetic engineering of methylotrophic bacteria has expanded greatly and strategies to produce fine and bulk chemicals with methylotrophs have been described. This review highlights the potential of these bacteria for the development of economically competitive bioprocesses based on methanol as an alternative carbon source, bringing together biological, technical and economic considerations.

引用

页码：107 / 115

页数：9

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