Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria

被引：226

作者：

Schrader, Jens ^{[1
]}

Schilling, Martin ^{[1
]}

Holtmann, Dirk ^{[1
]}

Sell, Dieter ^{[1
]}

Villela Filho, Murillo ^{[2
]}

Marx, Achim ^{[2
]}

Vorholt, Julia A. ^{[3
]}

机构：

[1] DECHEMA eV, Karl Winnacker Inst, Biochem Engn, D-60486 Frankfurt, Germany

[2] Evon Degussa GmbH, Sci Business Ctr Biotechnol, D-45772 Marl, Germany

[3] Swiss Fed Inst Technol, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 2009年 / 27卷 / 02期

关键词：

METHYLOBACTERIUM-EXTORQUENS AM1; POLY-BETA-HYDROXYBUTYRATE; SINGLE-CELL PROTEIN; L-SERINE PRODUCTION; L-LYSINE PRODUCTION; FED-BATCH CULTURE; METHYLOPHILUS-METHYLOTROPHUS; BACILLUS-METHANOLICUS; METHYLOBACILLUS-FLAGELLATUS; FORMALDEHYDE OXIDATION;

D O I：

10.1016/j.tibtech.2008.10.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Methanol is one of the building blocks in the chemical industry and can be synthesized either from petrochemical or renewable resources, such as biogas. Bioprocess technology with methylotrophic bacteria is well established, as illustrated by large-scale single-cell protein production in the past. During recent years, the first genomes of methylotrophs have been sequenced and significant progress in elucidating their metabolism has been made. In addition, the tool set for genetic engineering of methylotrophic bacteria has expanded greatly and strategies to produce fine and bulk chemicals with methylotrophs have been described. This review highlights the potential of these bacteria for the development of economically competitive bioprocesses based on methanol as an alternative carbon source, bringing together biological, technical and economic considerations.

引用

页码：107 / 115

页数：9

共 91 条

[1]

ALDRIDGE S, 2006, GEN ENG BIOTECH NEWS, V26

[2] The structure and function of the PQQ-containing quinoprotein dehydrogenases [J].

Anthony, C ;

Ghosh, M .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1998, 69 (01) :1-21

[3]

Anthony C., 1982, BIOCH METHYLOTROPHS

[4]

BEARDSMORE AJ, 1982, J GEN MICROBIOL, V128, P1423

[5] Production of heterologous protein by Methylobacterium extorquens in high cell density fermentation [J].

Bélanger, L ;

Figueira, MM ;

Bourque, D ;

Morel, L ;

Béland, M ;

Laramée, L ;

Groleau, D ;

Míguez, CB .

FEMS MICROBIOLOGY LETTERS, 2004, 231 (02) :197-204

[6] Growth and formation of poly(hydroxybutyric acid) by Methylobacterium rhodesianum at methanol concentrations of above 25 g/l [J].

Bormann, EJ ;

Leissner, M ;

Beer, B .

ACTA BIOTECHNOLOGICA, 1997, 17 (04) :279-289

[7] Comprehensive proteomics of Methylobacterium extorquens AM1 metabolism under single carbon and nonmethylotrophic conditions [J].

Bosch, Gundula ;

Skovran, Elizabeth ;

Xia, Qiangwei ;

Wang, Tansong ;

Taub, Fred ;

Miller, Jonathan A. ;

Lidstrom, Mary E. ;

Hackett, Murray .

PROTEOMICS, 2008, 8 (17) :3494-3505

[8]

BOURQUE D, 1992, APPL MICROBIOL BIOT, V37, P7

[9]

Bourque D, 1995, APPL MICROBIOL BIOT, V44, P367

[10] Role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine-secreting mutants [J].

Brautaset, T ;

Williams, MD ;

Dillingham, RD ;

Kaufmann, C ;

Bennaars, A ;

Crabbe, E ;

Flickinger, MC .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (07) :3986-3995

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