Notch and Wnt signaling in the emergence of hematopoietic stem cells

被引：54

作者：

Bigas, Anna ^{[1
]}

Guiu, Jordi ^{[1
]}

Gama-Norton, Leonor ^{[1
]}

机构：

[1] Inst Hosp del Mar Invest Med IMIM, Program Canc Res, Barcelona, Spain

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2013年 / 51卷 / 04期

关键词：

Notch; Wnt; HSC; Hematopoiesis; Embryonic hematopoiesis; AGM; WNT/BETA-CATENIN ACTIVITY; BETA-CATENIN; MICE LACKING; YOLK-SAC; ENDOTHELIAL-CELLS; LIGAND JAGGED1; AXIS FORMATION; MOUSE EMBRYO; IN-VIVO; ARTERIOVENOUS-MALFORMATIONS;

D O I：

10.1016/j.bcmd.2013.07.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：264 / 270

页数：7

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