Age dependent course of EAE in Aire-/- mice

被引：13
作者：
Aharoni, Rina [1 ]
Aricha, Revital [1 ]
Eilam, Raya [2 ]
From, Ido [1 ]
Mizrahi, Keren [1 ]
Arnon, Ruth [1 ]
Souroujon, Miriam C. [1 ,3 ]
Fuchs, Sara [1 ]
机构：
[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
[2] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel
[3] Open Univ Israel, Dept Nat Sci, Raanana, Israel
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 262卷 / 1-2期
关键词：
Autoimmune regulator (Aire); Regulatory T cells (Treg); Experimental autoimmune encephalomyelitis (EAE); Autoimmunity; Susceptibility; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; THYMIC EPITHELIAL-CELLS; MULTIPLE-SCLEROSIS; SELF-TOLERANCE; AIRE CONTROL; EXPRESSION; MECHANISMS; TRANSPLANTATION; ANTIGEN;
D O I：
10.1016/j.jneuroim.2013.06.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6 month old mice. In contrast, 2 month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：27 / 34
页数：8
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