Age dependent course of EAE in Aire-/- mice

被引：14

作者：

Aharoni, Rina ^{[1
]}

Aricha, Revital ^{[1
]}

Eilam, Raya ^{[2
]}

From, Ido ^{[1
]}

Mizrahi, Keren ^{[1
]}

Arnon, Ruth ^{[1
]}

Souroujon, Miriam C. ^{[1
,3
]}

Fuchs, Sara ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel

[3] Open Univ Israel, Dept Nat Sci, Raanana, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 262卷 / 1-2期

关键词：

Autoimmune regulator (Aire); Regulatory T cells (Treg); Experimental autoimmune encephalomyelitis (EAE); Autoimmunity; Susceptibility; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; THYMIC EPITHELIAL-CELLS; MULTIPLE-SCLEROSIS; SELF-TOLERANCE; AIRE CONTROL; EXPRESSION; MECHANISMS; TRANSPLANTATION; ANTIGEN;

D O I：

10.1016/j.jneuroim.2013.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6 month old mice. In contrast, 2 month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity. (C) 2013 Elsevier B.V. All rights reserved.

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页码：27 / 34

页数：8

相关论文

共 36 条

[1] Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1 [J].

Aharoni, R ;

Teitelbaum, D ;

Leitner, O ;

Meshorer, A ;

Sela, M ;

Arnon, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11472-11477

[2] Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate [J].

Aharoni, Rina ;

Vainshtein, Anya ;

Stock, Ariel ;

Eilam, Raya ;

From, Renana ;

Shinder, Vera ;

Arnon, Ruth .

JOURNAL OF AUTOIMMUNITY, 2011, 37 (03) :228-241

[3] Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE [J].

Aharoni, Rina ;

Eilam, Raya ;

Stock, Ariel ;

Vainshtein, Anya ;

Shezen, Elias ;

Gal, Hilah ;

Friedman, Nir ;

Arnon, Ruth .

JOURNAL OF NEUROIMMUNOLOGY, 2010, 225 (1-2) :100-111

[4] The cellular mechanism of Aire control of T cell tolerance [J].

Anderson, MS ;

Venanzi, ES ;

Chen, ZB ;

Berzins, SP ;

Benoist, C ;

Mathis, D .

IMMUNITY, 2005, 23 (02) :227-239

[5] Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis [J].

Aricha, Revital ;

Feferman, Tali ;

Fuchs, Sara ;

Souroujon, Miriam C. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (04) :2132-2139

[6] The susceptibility of Aire-/- mice to experimental myasthenia gravis involves alterations in regulatory T cells [J].

Aricha, Revital ;

Feferman, Tali ;

Scott, Hamish S. ;

Souroujon, Miriam C. ;

Berrih-Aknin, Sonia ;

Fuchs, Sara .

JOURNAL OF AUTOIMMUNITY, 2011, 36 (01) :16-24

[7] Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells [J].

Aschenbrenner, Katharina ;

D'Cruz, Louise M. ;

Vollmann, Elisabeth H. ;

Hinterberger, Maria ;

Emmerich, Jan ;

Swee, Lee Kim ;

Rolink, Antonius ;

Klein, Ludger .

NATURE IMMUNOLOGY, 2007, 8 (04) :351-358

[8] How defects in central tolerance impinge on a deficiency in regulatory T cells [J].

Chen, ZB ;

Benoist, C ;

Mathis, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) :14735-14740

[9] Spontaneous autoimmunity prevented by thymic expression of a single self-antigen [J].

DeVoss, Jason ;

Hou, Yafei ;

Johannes, Kellsey ;

Lu, Wen ;

Liou, Gregory I. ;

Rinn, John ;

Chang, Howard ;

Caspi, Rachel ;

Fong, Lawrence ;

Anderson, Mark S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2727-2735

[10] Overexpression of IFN-Induced protein 10 and its receptor CXCR3 in myasthenia gravis [J].

Feferman, T ;

Maiti, PK ;

Berrih-Aknin, S ;

Bismuth, J ;

Bidault, J ;

Fuchs, S ;

Souroujon, MC .

JOURNAL OF IMMUNOLOGY, 2005, 174 (09) :5324-5331

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