Scalp-recorded high-frequency oscillations in childhood epileptic encephalopathy with continuous spike-and-wave during sleep with different etiologies

被引：31

作者：

Gong, Pan ^{[1
]}

Xue, Jiao ^{[1
]}

Qian, Ping ^{[1
]}

Yang, Haipo ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Cai, Lixin ^{[1
]}

Bian, Kaigui ^{[2
]}

Yang, Zhixian ^{[1
]}

机构：

[1] Peking Univ, Dept Pediat, Hosp 1, 1 Xianmen St, Beijing 100034, Peoples R China

[2] Peking Univ, Inst Network Comp & Informat Syst, 5 Yiheyuan St, Beijing 100871, Peoples R China

来源：

BRAIN & DEVELOPMENT | 2018年 / 40卷 / 04期

基金：

美国国家科学基金会;

关键词：

High-frequency oscillations; Epileptic encephalopathy with continuous spike-and-wave during sleep; Scalp electroencephalography; Time-frequency analysis; ELECTRICAL STATUS EPILEPTICUS; SEIZURE-ONSET ZONE; TERM-FOLLOW-UP; SLOW SLEEP; GENERALIZED SPIKE; WEST SYNDROME; FAST RIPPLES; CHILDREN; EEG; DISCHARGES;

D O I：

10.1016/j.braindev.2017.12.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To investigate high-frequency oscillations (HFOs) in epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS) with different etiologies. Methods: Twenty-one CSWS patients treated with methylprednisolone were divided into structural group and genetic/unknown group. Comparisons were made between the two etiological groups: selected clinical variables including gender, age parameters, seizure frequencies and antiepileptic drugs; distribution of HFOs in pre-methylprednisolone electroencephalography (EEG) and percentage changes of HFOs and spikes after methylprednisolone treatment. Results: There were 7 patients (33%) in structural group and 14 patients (68%) in genetic/unknown group. No significant difference was found between the two groups regarding selected clinical variables. HFOs were found in 12 patients in premethylprednisolone EEG. The distribution of HFOs was focal and accordant with lesions in 5 of structural group, and it was also focal but in different brain regions in 7 of genetic/unknown group. The percentage reduction of total HFOs and spikes was 81% (158/195) and 19% (1956/10,037) in structural group, while 98% (315/323) and 55% (6658/12,258) in genetic/unknown group after methylprednisolone treatment. Conclusion: The etiologies had no distinct correlation with some clinical characteristics in CSWS. HFOs recorded on scalp EEG might not only be used as makers of seizure-onset zone (SOZ), but also have association with functional disruption of brain networks. Both HFOs and spikes reduced more in genetic/unknown patients than that in structural patients after methylprednisolone treatment and HFOs were more sensitive to treatment than spikes. (C) 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

引用

页码：299 / 310

页数：12

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