Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis

被引：14

作者：

Battisti, Vanessa ^{[1
]}

Maders, Liesi D. K. ^{[1
]}

Bagatini, Margarete D. ^{[1
]}

Battisti, Iara E. ^{[2
]}

Belle, Luziane P. ^{[3
]}

Santos, Karen F. ^{[1
]}

Maldonado, Paula A. ^{[1
]}

Thome, Gustavo R. ^{[1
]}

Schetinger, Maria R. C. ^{[1
]}

Morsch, Vera M. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Fronteira Sul, Dept Matemat, Cerro Largo, RS, Brazil

[3] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin, BR-97104900 Santa Maria, RS, Brazil

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2013年 / 67卷 / 03期

关键词：

Prostate cancer; Ectonucleotide pyrophosphatase/phosphodiesterase; Adenosine deaminase; ECTO-NUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; PHOSPHODIESTERASE-I; CELL-PROLIFERATION; BREAST-CANCER; SERUM; ATP; METABOLISM; NEOPLASIA; CARCINOMA; PLATELETS;

D O I：

10.1016/j.biopha.2012.12.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The relation between adenine nucleotides and cancer has already been described in literature. Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) act together to control nucleotide levels, we aimed to investigate the role of these enzymes in prostate cancer (PCa). E-NPP and ADA activities were determined in serum and platelets of PCa patients and controls. We also verified the influence of the Gleason score, bone metastasis and treatment in the enzyme activities. Platelets and serum E-NPP activity increased, whereas ADA activity in serum decreased in PCa patients. In addition, Gleason score, metastasis and treatment influenced E-NPP and ADA activities. We may propose that E-NPP and ADA are involved in the development of PCa. Moreover, E-NPP and ADA activities are modified in PCa patients with distinct Gleason score, with bone metastasis, as well as in patients under treatment. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：203 / 208

页数：6

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