Is the use of low molecular weight heparin a rational choice during pregnancy in patients with a mechanical heart valve: a report of three cases

被引：7

作者：

Guner, Ahmet ^{[1
]}

Bayam, Emrah ^{[1
]}

Kalkan, Semih ^{[1
]}

Gunduz, Sabahattin ^{[1
]}

Ozkan, Mehmet ^{[1
]}

机构：

[1] Kartal Kosuyolu High Special Training & Res Hosp, Dept Cardiol, Istanbul, Turkey

来源：

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY | 2019年 / 47卷 / 01期

关键词：

Low molecular weight heparin; mechanical heart valve; prosthetic valve thrombosis; THROMBOLYTIC THERAPY; ANTI-XA; WOMEN; ANTICOAGULATION; THROMBOSIS;

D O I：

10.5543/tkda.2018.83364

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pregnancy is associated with an increased risk of valve thrombosis in patients with a mechanical prosthetic heart valve. The administration of low molecular weight heparin (LMWH) with regular anti-factor Xa assessment is a recommended treatment modality for these patients. Presently described are 3 cases of therapy with LMWH during pregnancy. Despite frequent anti-factor Xa monitoring, not surprisingly, all of them developed prosthetic valve thrombosis.

引用

页码：63 / 68

页数：6

共 15 条

[1] A case series of LMWH use in pregnancy: Should trough anti-Xa levels guide dosing?
Berresheim, Michelle
Wilkie, Jodi
Nerenberg, Kara A.
Ibrahim, Quazi
Bungard, Tammy J.
[J]. THROMBOSIS RESEARCH, 2014, 134 (06) : 1234 - 1240
[2] Anticoagulation of pregnant women with mechanical heart valves -: A systematic review of the literature
Chan, WS
Anand, S
Ginsberg, JS
[J]. ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (02) : 191 - 196
[3] Anticoagulation Therapy for Pregnant Women With Mechanical Prosthetic Heart Valves How to Improve Safety?
Elkayam, Uri
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (22) : 2692 - 2695
[4] Challenges of Anticoagulation Therapy in Pregnancy
Fogerty A.E.
[J]. Current Treatment Options in Cardiovascular Medicine, 2017, 19 (10)
[5] Monitoring of Anti-Xa in Pregnant Patients With Mechanical Prosthetic Valves Receiving Low-Molecular-Weight Heparin: Peak or Trough Levels?
Goland, Sorel
Schwartzenberg, Shmuel
Fan, John
Kozak, Natasha
Khatri, Nudrat
Elkayam, Uri
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2014, 19 (05) : 451 - 456
[6] Pregnancy outcome of first trimester exposure to the vitamin K antagonist phenprocoumon depends on duration of treatment
Huettel, Eleanor
Padberg, Stephanie
Meister, Reinhard
Beck, Evelin
Schaefer, Christof
[J]. THROMBOSIS AND HAEMOSTASIS, 2017, 117 (05) : 870 - 879
[7] Maternal complications and pregnancy outcome in women with mechanical prosthetic heart valves treated with enoxaparin
McLintock, C.
McCowan, L. M. E.
North, R. A.
[J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2009, 116 (12) : 1585 - 1592
[8] Nishimura RA, 2014, J THORAC CARDIOV SUR, V148, pE1, DOI [10.1016/j.jacc.2014.02.537, 10.1016/j.jtcvs.2014.05.014, 10.1016/j.jacc.2014.02.536]
[9] Low molecular weight heparin for the prophylaxis of thromboembolism in women with prosthetic mechanical heart valves during pregnancy
Oran, B
Lee-Paritz, A
Anselli, J
[J]. THROMBOSIS AND HAEMOSTASIS, 2004, 92 (04) : 747 - 751
[10] Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial
Ozkan, Mehmet
Gunduz, Sabahattin
Gursoy, Ozan Mustafa
Karakoyun, Suleyman
Astarcioglu, Mehmet Ali
Kalcik, Macit
Aykan, Ahmet Cagri
Cakal, Beytullah
Bayram, Zubeyde
Oguz, Ali Emrah
Erturk, Emre
Yesin, Mahmut
Gokdeniz, Tayyar
Duran, Nilufer Eksi
Yildiz, Mustafa
Esen, Ali Metin
[J]. AMERICAN HEART JOURNAL, 2015, 170 (02) : 409 - U284

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