The impact of post-transcriptional regulation in the p53 network

被引：41
作者：
Freeman, Justin A. [1 ]
Espinosa, Joaquin M. [1 ]
机构：
[1] Univ Colorado, HHMI, Boulder, CO 80309 USA
来源：
BRIEFINGS IN FUNCTIONAL GENOMICS | 2013年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
p53; post-transcriptional regulation; RNA-binding proteins; miRNA; CELL-CYCLE ARREST; DNA-DAMAGE; DOWN-REGULATION; TRANSLATIONAL REPRESSION; APOPTOTIC RESPONSE; GENE-EXPRESSION; GROWTH ARREST; FEEDBACK LOOP; BINDING; PROTEIN;
D O I：
10.1093/bfgp/els058
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The p53 transcription factor regulates the synthesis of mRNAs encoding proteins involved in diverse cellular stress responses such as cell-cycle arrest, apoptosis, autophagy and senescence. In this review, we discuss how these mRNAs are concurrently regulated at the post-transcriptional level by microRNAs (miRNAs) and RNA-binding proteins (RBPs), which consequently modify the p53 transcriptional program in a cell type- and stimulus-specific manner. We also discuss the action of specific miRNAs and RBPs that are direct transcriptional targets of p53 and how they act coordinately with protein-coding p53 target genes to orchestrate p53-dependent cellular responses.
引用
收藏
页码：46 / 57
页数：12
相关论文
共 103 条
[81]   Blinded by the Light: The Growing Complexity of p53 [J].
Vousden, Karen H. ;
Prives, Carol .
CELL, 2009, 137 (03) :413-431
[82]   BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death [J].
Wade, Mark ;
Rodewald, Luo Wei ;
Espinosa, Joaquin M. ;
Wahl, Geoffrey M. .
CELL CYCLE, 2008, 7 (13) :1973-1982
[83]  
WALDMAN T, 1995, CANCER RES, V55, P5187
[84]   Let-7/miR-98 regulate Fas and Fas-mediated apoptosis [J].
Wang, S. ;
Tang, Y. ;
Cui, H. ;
Zhao, X. ;
Luo, X. ;
Pan, W. ;
Huang, X. ;
Shen, N. .
GENES AND IMMUNITY, 2011, 12 (02) :149-154
[85]   HuR regulates p21 mRNA stabilization by UV light [J].
Wang, WG ;
Furneaux, H ;
Cheng, HM ;
Caldwell, MC ;
Hutter, D ;
Liu, YS ;
Holbrook, N ;
Gorospe, M .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (03) :760-769
[86]   A global map of p53 transcription-factor binding sites in the human genome [J].
Wei, CL ;
Wu, Q ;
Vega, VB ;
Chiu, KP ;
Ng, P ;
Zhang, T ;
Shahab, A ;
Yong, HC ;
Fu, YT ;
Weng, ZP ;
Liu, JJ ;
Zhao, XD ;
Chew, JL ;
Lee, YL ;
Kuznetsov, VA ;
Sung, WK ;
Miller, LD ;
Lim, B ;
Liu, ET ;
Yu, Q ;
Ng, HH ;
Ruan, YJ .
CELL, 2006, 124 (01) :207-219
[87]   Microglia-derived TGF-β as an important regulator of glioblastoma invasion -: an inhibition of TGF-β-dependent effects by shRNA against human TGF-β type II receptor [J].
Wesolowska, A. ;
Kwiatkowska, A. ;
Slomnicki, L. ;
Dembinski, M. ;
Master, A. ;
Sliwa, M. ;
Franciszkiewicz, K. ;
Chouaib, S. ;
Kaminska, B. .
ONCOGENE, 2008, 27 (07) :918-930
[88]   KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene [J].
Wu, GS ;
Burns, TF ;
McDonald, ER ;
Jiang, W ;
Meng, R ;
Krantz, ID ;
Kao, G ;
Gan, DD ;
Zhou, JY ;
Muschel, R ;
Hamilton, SR ;
Spinner, NB ;
Markowitz, S ;
Wu, G ;
ElDeiry, WS .
NATURE GENETICS, 1997, 17 (02) :141-143
[89]   Negative regulation of bcl-2 expression by p53 in hematopoietic cells [J].
Wu, YL ;
Mehew, JW ;
Heckman, CA ;
Arcinas, M ;
Boxer, LM .
ONCOGENE, 2001, 20 (02) :240-251
[90]   miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress [J].
Xiao, Jiening ;
Lin, Huixian ;
Luo, Xiaobin ;
Luo, Xiaoyan ;
Wang, Zhiguo .
EMBO JOURNAL, 2011, 30 (03) :524-532
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