The impact of post-transcriptional regulation in the p53 network

被引：41
作者：
Freeman, Justin A. [1 ]
Espinosa, Joaquin M. [1 ]
机构：
[1] Univ Colorado, HHMI, Boulder, CO 80309 USA
来源：
BRIEFINGS IN FUNCTIONAL GENOMICS | 2013年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
p53; post-transcriptional regulation; RNA-binding proteins; miRNA; CELL-CYCLE ARREST; DNA-DAMAGE; DOWN-REGULATION; TRANSLATIONAL REPRESSION; APOPTOTIC RESPONSE; GENE-EXPRESSION; GROWTH ARREST; FEEDBACK LOOP; BINDING; PROTEIN;
D O I：
10.1093/bfgp/els058
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The p53 transcription factor regulates the synthesis of mRNAs encoding proteins involved in diverse cellular stress responses such as cell-cycle arrest, apoptosis, autophagy and senescence. In this review, we discuss how these mRNAs are concurrently regulated at the post-transcriptional level by microRNAs (miRNAs) and RNA-binding proteins (RBPs), which consequently modify the p53 transcriptional program in a cell type- and stimulus-specific manner. We also discuss the action of specific miRNAs and RBPs that are direct transcriptional targets of p53 and how they act coordinately with protein-coding p53 target genes to orchestrate p53-dependent cellular responses.
引用
收藏
页码：46 / 57
页数：12
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