Chronic rhinosinusitis: Future treatments and unmet needs

被引:8
作者
Giri, Sneha [1 ]
Schneider, Alexander L. [1 ]
Tan, Bruce K. [1 ]
机构
[1] Northwestern Univ, Dept Otolaryngol Head & Neck Surg, Feinberg Sch Med, Chicago, IL USA
基金
美国国家卫生研究院;
关键词
Chronic rhinosinusitis; type; 2; inflammation; biologics; endoscopic sinus surgery;
D O I
10.1016/j.jaci.2022.05.016
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal cavity and paranasal sinuses that affects 10% of the US population and presents with 2 major phenotypes: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Classification of CRS on the basis of specific pathobiologic mechanisms, also termed endotyping, finds that the type 2 endotype (characterized by cytokines such as IL-4, IL-5, and IL-13; tissue eosinophilia; and local IgE production) comprises 80% to 90% of patients with CRSwNP and 30% to 50% of patients with CRSsNP with severe disease requiring endoscopic sinus surgery (ESS) in Western countries. CRSwNP in Asia and CRSsNP have more endotypic heterogeneity, with significant subpopulations that have combinations of type 1 (IFN-gamma and IL-12), type 2, and type 3 (IL-17 and IL-22) inflammation.(1)
引用
收藏
页码:287 / 290
页数:4
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