Update on Burkitt Lymphoma

被引：54

作者：

Dunleavy, Kieron ^{[1
]}

Little, Richard F. ^{[2
]}

Wilson, Wyndham H. ^{[1
]}

机构：

[1] NCI, Lymphoid Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[2] NCI, HIV & Stem Cell Therapeut, CTEP, Bethesda, MD 20892 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 06期

关键词：

Burkitt lymphoma; MYC; TCF3; CCND3; ID3; Risk-adapted; Endemic; Sporadic; PROMOTES GENOMIC INSTABILITY; MODIFIED CODOX-M/IVAC; NON-HODGKINS-LYMPHOMA; DOSE-ADJUSTED EPOCH; B-CELL LYMPHOMA; ADULT BURKITT; CHEMOTHERAPY; RITUXIMAB; THERAPY; APOPTOSIS;

D O I：

10.1016/j.hoc.2016.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because of its rarity and high curability, progress in advancing therapeutics in Burkitt lymphoma (BL) has been difficult. Over recent years, several new mutations that cooperate with MYC have been identified, and this has paved the way for testing novel agents in the disease. One of the challenges of most standard approaches typically used is severe treatment related toxicity that often leads to discontinuation of therapy. To that point, there has been recent success developing intermediate intensity approaches that are well tolerated in all patient groups and maintain high cure rates in a multicenter setting.

引用

页码：1333 / +

页数：12

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