Cardiovascular disease in diabetes

被引：18
作者：
Yamagishi, S [1 ]
Nakamura, K [1 ]
Matsui, T [1 ]
Takenaka, K [1 ]
Jinnouchi, Y [1 ]
Imaizumi, T [1 ]
机构：
[1] Kurume Univ, Sch Med, Dept Internal Med 3, Kurume, Fukuoka 8300011, Japan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 03期
关键词：
AGES; atherosclerosis; diabetes; oxidative stress; renin-angiotensin system;
D O I：
10.2174/138955706776073501
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia. advanced glycation end products (AGES) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.
引用
收藏
页码：313 / 318
页数：6
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