O-GlcNAc Modification Prevents Peptide-Dependent Acceleration of α-Synuclein Aggregation

被引：52
作者：
Marotta, Nicholas P. [1 ,2 ]
Cherwien, Carli A. [1 ,2 ]
Abeywardana, Tharindumala [1 ,2 ]
Pratt, Matthew R. [1 ,2 ]
机构：
[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Mol & Computat Biol, Los Angeles, CA 90089 USA
来源：
CHEMBIOCHEM | 2012年 / 13卷 / 18期
关键词：
aggregation; glycosylation; O-GlcNAc; Parkinson's disease; synuclein; PARKINSONS-DISEASE; POSTTRANSLATIONAL MODIFICATIONS; N-ACETYLGLUCOSAMINE; LEWY BODIES; HUMAN BRAIN; GENE; PHOSPHORYLATION; FIBRILLATION; MUTATION; UBIQUITINATION;
D O I：
10.1002/cbic.201200478
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：2665 / 2670
页数：6
相关论文
共 47 条
  • [1] Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets
    Alfaro, Joshua F.
    Gong, Cheng-Xin
    Monroe, Matthew E.
    Aldrich, Joshua T.
    Clauss, Therese R. W.
    Purvine, Samuel O.
    Wang, Zihao
    Camp, David G., II
    Shabanowitz, Jeffrey
    Stanley, Pamela
    Hart, Gerald W.
    Hunt, Donald F.
    Yang, Feng
    Smith, Richard D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (19) : 7280 - 7285
  • [2] α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    Bartels, Tim
    Choi, Joanna G.
    Selkoe, Dennis J.
    [J]. NATURE, 2011, 477 (7362) : 107 - U123
  • [3] From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease
    Bellucci, Arianna
    Zaltieri, Michela
    Navarria, Laura
    Grigoletto, Jessica
    Missale, Cristina
    Spano, PierFranco
    [J]. BRAIN RESEARCH, 2012, 1476 : 183 - 202
  • [4] Borghammer P, 2010, BRAIN STRUCT FUNCT, V214, P303, DOI 10.1007/s00429-010-0246-0
  • [5] α-synuclein locus duplication as a cause of familial Parkinson's disease
    Chartier-Harlin, MC
    Kachergus, J
    Roumier, C
    Mouroux, V
    Douay, X
    Lincoln, S
    Levecque, C
    Larvor, L
    Andrieux, J
    Hulihan, M
    Waucquier, N
    Defebvre, L
    Amouyel, P
    Farrer, M
    Destée, A
    [J]. LANCET, 2004, 364 (9440) : 1167 - 1169
  • [6] Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
    Chen, Li
    Periquet, Magali
    Wang, Xu
    Negro, Alessandro
    McLean, Pamela J.
    Hyman, Bradley T.
    Feany, Mel B.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (11) : 3257 - 3265
  • [7] Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
    Cremades, Nunilo
    Cohen, Samuel I. A.
    Deas, Emma
    Abramov, Andrey Y.
    Chen, Allen Y.
    Orte, Angel
    Sandal, Massimo
    Clarke, Richard W.
    Dunne, Paul
    Aprile, Francesco A.
    Bertoncini, Carlos W.
    Wood, Nicholas W.
    Knowles, Tuomas P. J.
    Dobson, Christopher M.
    Klenerman, David
    [J]. CELL, 2012, 149 (05) : 1048 - 1059
  • [8] Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
    Drzezga, A
    Lautenschlager, N
    Siebner, H
    Riemenschneider, M
    Willoch, F
    Minoshima, S
    Schwaiger, M
    Kurz, A
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (08) : 1104 - 1113
  • [9] Acceleration of α-synuclein aggregation by homologous peptides
    Du, Hai-Ning
    Li, Hong-Tao
    Zhang, Feng
    Lin, Xiao-Jing
    Shi, Jia-Hao
    Shi, Yan-Hong
    Ji, Li-Na
    Hu, Jun
    Lin, Dong-Hai
    Hu, Hong-Yu
    [J]. FEBS LETTERS, 2006, 580 (15): : 3657 - 3664
  • [10] CORTICAL GLUCOSE-METABOLISM IN PARKINSONS-DISEASE WITHOUT DEMENTIA
    EBERLING, JL
    RICHARDSON, BC
    REED, BR
    WOLFE, N
    JAGUST, WJ
    [J]. NEUROBIOLOGY OF AGING, 1994, 15 (03) : 329 - 335
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