Osteomyelitis due to methicillin-resistant Staphylococcus aureus successfully treated by an oral combination of minocycline and trimethoprim-sulfamethoxazole

被引：5

作者：

Sato, Kojiro ^{[1
]}

Yazawa, Hiroaki ^{[1
]}

Ikuma, Daisuke ^{[1
]}

Maruyama, Takashi ^{[1
]}

Kajiyama, Hiroshi ^{[1
]}

Mimura, Toshihide ^{[1
]}

机构：

[1] Saitama Med Univ, Fac Med, Dept Rheumatol & Appl Immunol, Morohongo 38, Saitama 3500495, Japan

来源：

SAGE OPEN MEDICAL CASE REPORTS | 2019年 / 7卷

关键词：

Methicillin-resistant Staphylococcus aureus; osteomyelitis; minocycline; trimethoprim-sulfamethoxazole; linezolid; ANTIBIOTICS; INFECTIONS;

D O I：

10.1177/2050313X19841465

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most of the anti-methicillin-resistant Staphylococcus aureus drugs available in Japan are administered intravenously, except for linezolid, which can also be administered orally. Here, we report a lupus patient with methicillin-resistant S. aureus-induced osteomyelitis. Linezolid had to be stopped due to severe anemia. In an effort to treat her on an outpatient basis, we planned to use a combination of minocycline and trimethoprim-sulfamethoxazole that exhibited in vitro sensitivity against the methicillin-resistant S. aureus detected, and rifampicin is used against methicillin-resistant S. aureus in certain cases. The use of rifampicin increased the level of C-reactive protein even though the prednisolone dose used was doubled, so we gave up using it. The combined application of oral minocycline and trimethoprim-sulfamethoxazole, however, controlled the inflammation, and the patient was able to be discharged. Fourteen months later, we discontinued the administration of both drugs and there has been no relapse more than a year. This combination of antibiotics may be useful, especially when patients want to be treated on an outpatient basis.

引用

页数：5

共 6 条

[1] Linezolid and reversible myelosuppression [J].

Green, SL ;

Maddox, LC ;

Huttenbach, ED .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (10) :1291-1291

[2] 75% success rate after open debridement, exchange of tibial insert, and antibiotics in knee prosthetic joint infections Report on 145 cases from the Swedish Knee Arthroplasty Register [J].

Holmberg, Anna ;

Thorhallsdottir, Valdis Gudrun ;

Robertsson, Otto ;

W-Dahl, Annette ;

Stefansdottir, Anna .

ACTA ORTHOPAEDICA, 2015, 86 (04) :457-462

[3] Oral versus Intravenous Antibiotics for Bone and Joint Infection [J].

Li, H. -K. ;

Rombach, I. ;

Zambellas, R. ;

Walker, A. S. ;

McNally, M. A. ;

Atkins, B. L. ;

Lipsky, B. A. ;

Hughes, H. C. ;

Bose, D. ;

Kumin, M. ;

Scarborough, C. ;

Matthews, P. C. ;

Brent, A. J. ;

Lomas, J. ;

Gundle, R. ;

Rogers, M. ;

Taylor, A. ;

Angus, B. ;

Byren, I. ;

Berendt, A. R. ;

Warren, S. ;

Fitzgerald, F. E. ;

Mack, D. J. F. ;

Hopkins, S. ;

Folb, J. ;

Reynolds, H. E. ;

Moore, E. ;

Marshall, J. ;

Jenkins, N. ;

Moran, C. E. ;

Woodhouse, A. F. ;

Stafford, S. ;

Seaton, R. A. ;

Vallance, C. ;

Hemsley, C. J. ;

Bisnauthsing, K. ;

Sandoe, J. A. T. ;

Aggarwal, I. ;

Ellis, S. C. ;

Bunn, D. J. ;

Sutherland, R. K. ;

Barlow, G. ;

Cooper, C. ;

Geue, C. ;

McMeekin, N. ;

Briggs, A. H. ;

Sendi, P. ;

Khatamzas, E. ;

Wangrangsimakul, T. ;

Wong, T. H. N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (05) :425-436

[4]

Liu C, 2011, CLIN INFECT DIS, V52, P285, DOI [10.1093/cid/cir034, 10.1093/cid/ciq146]

[5] Update on rifampin drug interactions .3. [J].

Strayhorn, VA ;

Baciewicz, AM ;

Self, TH .

ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (21) :2453-2458

[6] A 5-day course of oral desensitization to trimethoprim/sulfamethoxazole (T/S) in patients with human immunodeficiency virus type-1 infection who were previously intolerant to T/S [J].

Yoshizawa, S ;

Yasuoka, A ;

Kikuchi, Y ;

Honda, M ;

Gatanaga, H ;

Tachikawa, N ;

Hirabayashi, Y ;

Oka, S .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2000, 85 (03) :241-244

← 1 →