A new efficient method for one-pot conversions of aryl carboxylic acids into nitriles without solvent

被引：12

作者：

Cao, Yu-Qing ^{[1
]}

Zhang, Zhan ^{[1
]}

Guo, Yan-Xin ^{[1
]}

机构：

[1] Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2008年 / 83卷 / 10期

关键词：

aryl carboxylic acids; nitriles; thionyl chloride; solvent-free; dehydration;

D O I：

10.1002/jctb.1961

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new efficient method for synthesising nitriles, important organic reagents, is reported in this paper. In an environmentally benign solvent-free system, aryl carboxylic acids were converted into the corresponding nitriles via one-pot reactions, by amidation with ethyl carbamate followed by dehydration with thionyl chloride, in excellent yields. The results showed that the method has the advantages of lower cost, higher yield, less pollution and greater ease of work-up. (c) 2008 Society of Chemical Industry.

引用

页码：1441 / 1444

页数：4

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